background: it is well known that the development of brain oxidative stress is one of the most serious complications of arterial hypertension that evokes brain tissue damage. the aim of this study was to examine the effects of atorvastatin treatment (20 mg/kg/day), as an antioxidant, to prevent the brain tissue oxidative stress in the hypertensive (htn) rats. methods: experiments were performed...

background: diabetes mellitus in some clinical cases is accompanied with hyperalgesia. in this study, we evaluated the possible beneficial effect of chronic pelargonidin (pg) treatment on hyperalgesia in streptozotocin (stz)-diabetic neuropathic rat. methods: male wistar rats (n = 56) were divided into seven groups, i.e. control, diabetic, pg-treated control, pg (single- and multiple-dose)-trea...

background: gallic acid (ga) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti‑inflammatory, anti‑cancer, and anti‑fungal properties. the aim of this study was to assess the protective effect of ga on cyclophosphamide (cpa)‑induced hepatotoxicity in male wistar rats. methods: sixty rats were grouped into six groups of 10 rats per group. group 1 recei...

cardiac disorders remain one of the most important causes of death in the world. oxidative stress has been suggested as one of the molecular mechanisms involved in drug-induced cardiac toxicity. recently, several natural products have been utilized in different studies with the aim to protect the progression of oxidative stress-induced cardiac disorders. there is a large body of evidence that a...

sperm is particularly susceptible to reactive oxygen species (ros) during critical phases of spermiogenesis. however, the level of seminal ros is restricted by seminal antioxidants which have beneficial effects on sperm parameters and developmental potentials. mitochondria and sperm plasma membrane are two major sites of ros generation in sperm cells. besides, leukocytes including polymer phonu...

The objectives of this special issue on paraoxonases (PONs) are to bring the latest aspects of paraoxonases (PON 1, 2, 3) research on the genetics, biochemistry, cell biology, and structural biology of PONs. The issue also addresses the role of PONs in human diseases (cardiovascular, cancer, renal failure, and gastrointestinal disorders). Inflammatory and oxidative stress-related diseases, such...

exposure to air pollutants, steel dust or other occupational and environmental hazards as oxidative stress have adverse effects on subway workers' health. oxidative stress generates an excessive amount of reactive oxygen species (ros) and oxygen free radicals during their work time in the tunnels. once dna is repaired, urinary 8-hydroxy-deoxyguanosine (8-ohdg) is excreted in the urine. therefor...

The recent report on acute organo-phosphorus pesticide poisoning, oxidative damage, haemoglobin level and total leukocyte is very interesting. Hundekari et al. noted that “cholinesterase inhibition may initiate cellular dysfunction leading to acetylcholine induced oxidative damage.” This work is very useful information in clinical toxicology. However, there are many points to be considered. Fir...

background: this study investigated the protective effects of aqueous extracts of anogeissus leiocarpus (dc) guill & perr (combretaceae) and terminalia avicennioides guill & perr (combretaceae) root barks, as well as their 1:1 (w/w) mixture on liver redox and haematological parameters of diethylnitrosamine-treated rats. methods: rats were orally administered distilled water, diethylnitrosamine ...