The Hairy and Enhancer-of-Split (HES) family of transcriptional repressors plays important roles in pattern formation during development throughout the animal kingdom. Generally, HES proteins repress the expression of genes specific for neighboring tissues to maintain the nature of cells expressing HES proteins, resulting in pattern formation. Xhairy2b, a Xenopus HES, establishes the prospectiv...

Early in development, the behavior of neuroepithelial cells is controlled by several factors acting in a developmentally regulated manner. Recently it has been shown that diffusible factors contained within embryonic cerebrospinal fluid (CSF) promote neuroepithelial cell survival, proliferation, and neurogenesis in mesencephalic explants lacking any known organizing center. In this paper, we sh...

The dorsal gastrula organizer plays a fundamental role in establishment of the vertebrate axis. We demonstrate that the zebrafish bozozok (boz) locus is required at the blastula stages for formation of the embryonic shield, the equivalent of the gastrula organizer and expression of multiple organizer-specific genes. Furthermore, boz is essential for specification of dorsoanterior embryonic stru...

When duplex DNA is altered in almost any way (replicated, recombined, or repaired), single strands of DNA are usually intermediates, and single-stranded DNA binding (SSB) proteins are present. These proteins have often been described as inert, protective DNA coatings. Continuing research is demonstrating a far more complex role of SSB that includes the organization and/or mobilization of all as...

At a minimum, these errors, omissions, and borrowings raise questions about the depth of Dr Harding's research and the originality of his analysis. I came into embryology as a postdoctoral fellow in 1974, when the subject was rather unfashionable and neglected. Over my first few years I spent long hours in the library and read with fascination of an earlier "golden age" between the two World Wa...

Strategi pemasaran suatu perusahaan menjadi faktor yang sangat penting dan berpengaruh. Industri bisnis di sektor dekorasi telah mengalami perkembangan signifikan dalam beberapa tahun terakhir. Hal ini mengilhami banyak pengusaha untuk memulai usaha baru atau memperluas sudah ada, menempatkan mereka persaingan langsung dengan lain. Metode observasi dilakukan selama 3 (tiga) bulan melakukan pene...

Many of the experimental observations on which the understanding of inductive interactions during vertebrate development are based were originally made using amphibian embryos (reviewed by Slack and Tannahill, 1992). In amphibians, induction of dorsal mesoderm and specification of the anteriorposterior axis begin at the time of gastrulation, in Spemann’s organizer region, in response to signals...