A sensitive, selective, precise and stability indicating a high-performance thin layer chromatographic method for the analysis of rufinamide (Rf) in bulk drug and its formulations was developed and validated. The method employed thin layer chromatography aluminum plates precoated with silica gel 60 F254 as the stationary phase. The solvent system consisted of chloroform : methanol : glacial ace...

The absorption, metabolism, and excretion of darapladib, a novel inhibitor of lipoprotein-associated phospholipase A2, was investigated in healthy male subjects using [C]-radiolabeled material in a bespoke study design. Disposition of darapladib was compared following single i.v. and both single and repeated oral administrations. The anticipated presence of low circulating concentrations of dru...

A novel stability-indicating gradient reverse phase liquid chromatographic method was developed for the quantitative determination of process related impurities and forced degradation products of Dipyridamole in Dipyridamole retard capsules. This method is able separate all seven known impurities which includes two newly identified potential degradant impurities.The method was developed by usin...

BACKGROUND Nattokinases/Subtilisins (EC 3.4.21.62) belong to the second large family of serine proteases, which gain significant attention and play important role in many biotechnology processes. Thus, a number of nattokinases/subtilisins from various Bacillus species, especially from B. subtilis strains, extensively have been investigated to understand their biochemical and physical properties...

with the emergence of the theory of control in linguistics and the introduction of pro as one of the empty categories in government and binding, one can find the investigation of the interpretive properties of pro in the generative agenda. within these studies, especially within the minimalist tradition, some new properties were added to the list while others lost their values. as such, a new p...

Polycyclic aromatic hydrocarbons (PAHs) are a class of carcinogenic compounds that are both naturally and artificially produced. Many PAHs are pro-carcinogens that require metabolic activation. Recently, it has been shown that PAH can induce DNA single strand cleavage and formation of PAH-DNA covalent adduct upon irradiation with UVA light. The light-induced DNA cleavage parallels phototoxicity...

kentucky bluegrass (poa pratensis l.) is one of the most widely used turfgrasses for home lawns, golf courses, parks, and athletic fields in temperate climates. oxidative stress caused by drought stress is a major limiting factor for grass cultivation in arid and semi-arid regions. the objective of this study was to investigate whether prohexadione-calcium (pro-ca) may play a role in promoting ...