RZT is potent anti migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B and 5-HT 1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid action, which is required for immediate relief from migraine pain. Marketed freeze dried tablet of RZT is available. Freeze drying is cumbersome and it yields a ...

Sildenafil citrate is an oral therapy for erectile dysfunction (ED). Sildenafil, a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5 (PDE5), has been reported to be effective in men with ED associated with diabetes and prostate cancer, and in psychogenic ED. The main objective of this study is to prepare more effective, rapidly disintegrating and rapid onse...

An antipyretic analgesic drug called paracetamol is used in children to treat mild moderate pain and fever. Orally Disintegrating Tablet (ODT), a medicine that dissolves seconds, was created help who have difficulty swallowing tablets. The purpose of this study determine the effect changes concentration chitosan as disintegrant formulation ODT paracetamol. These tablets are made using wet granu...

Lorazepam a benzodiazepine drug is used as an antianxiety, sedative, hypnotic, and anticonvulsant drug. Bypassing the enterohepatic recirculation and first-pass metabolism of lorazepam by sublingual delivery of this drug may accelerate the onset of its action. The objective of this study was the formulation, optimization and in vitro characterization of mucoadhesive sublingual tablets of loraze...