Squamous cell carcinoma is the most common malignant neoplasm of the Oral Cavity, usually affecting individuals over 50 years of age. It rarely occurs in patients who are less than 40 years old (0.4-5.5%). However, since it is so rare, when cases occur they are often misdiagnosed and inappropriately treated leading to delay in definitive treatment. This report describes a case of squamous cell ...

Xenobiotic metabolism in oral tissues, especially in the tongue, has never been reported. In the present study, the metabolic activation/detoxification ability of promutagens in the tongue and the expression levels of related enzymes were investigated. Quantitative PCR analysis of rat tongue demonstrated constitutive messenger RNA (mRNA) expression of numerous drug-metabolizing enzymes. In part...

BACKGROUND The present study aimed at evaluating the expression intensities of the Mcm-2 protein and Ki-67 antigen in squamocellular carcinomas of the oral cavity and comparing their prognostic value. MATERIALS AND METHODS Forty-nine patients, operated on and treated with radiotherapy for carcinoma of the oral cavity floor and/or the mobile part of the tongue, were retrospectively analyzed. ...

INTRODUCTION Oral cancers are the 10th most common cancer worldwide, with oral tongue squamous cell carcinoma (OTSCC) having the highest incidence. Surgery and radiotherapy (RT), the mainstay treatments for OTSCC, impact on the patients’ quality of life and the 50% 5-year survival has remained unchanged for 40 years. Cancer stem cells (CSCs) have been proposed to be the origin of many cancers, ...

Oral squamous cell carcinoma (SCC) represents 90% to 95% of all malignant neoplasms of the oral cavity. It is classically regarded as an adult disease entity and has a high correlation with alcohol and tobacco consumption.1 Oral SCC occurs in several well established intraoral sites, including the floor of mouth, tongue (most common), gingiva, lips, and buccal mucosa. It might also present in t...

Caveolin-1 (Cav-1), a major structural protein of caveolae, is an integral membrane protein which plays an important role in the progression of carcinoma. However, whether Cav-1 acts as a tumor promoter or a tumor suppressor still remains controversial. For example, the tumor-promoting function of Cav-1 has been found in renal cancer, prostate cancer, tongue squamous cell carcinoma (SCC), lung ...

Spindle cell carcinoma (SCSCC) with osteoid and/or cartilage formation in the head and neck is rare; only one case was reported tongue. Herein, we report an SCSCC of tongue developed 85-year-old man, then review report.

it has been argued that oral lichen planus (olp) may increase the risk of oral cancer. patients with olp may be at an increased risk for developing of oscc (oral squamous cell carcinoma). here, the author reports a case of olp initially presenting with a clearly benign olp lesion that transformed into oscc over a course of 18 months. this report may provide a clear evidence for olp lesion as a ...

BACKGROUND Human papilloma virus (HPV) is an important risk factor for head and neck cancer, specifically oropharyngeal cancer, but its association with oral tongue squamous cell carcinoma (SCC) is uncertain. The objectives were to determine the HPV16 prevalence in oral tongue SCCs, its integration status and to correlate the expression of oncogenic proteins with targets. METHODS In this case...

This study was designed to estimate objectively the hardness of the oral mucosa which is not directly supported by the bone. A new, easy-to-use hardness-measurement apparatus for measuring the oral mucosa free of the underlining bone was manufactured for trial use. The hardness values of the oral mucosa were evaluated quantitatively, resulting from pressing 2 mm into the mucosa with a 2-mm-in-d...