pemphigus vulgaris (pv) is one of the most common and studied autoimmune disorders of skin. the knock down of desmogleins in the skin by igg antibodies will eventually leads to mucocutaneous problems in both genders. targeting the cardinal molecules involved in the pathways of immune response is the main goal of given therapy. with regard to the side effects of long term use of immunosuppressiv...

pemphigus vulgaris (pv) is an autoimmune blistering disorder of the skin or mucosa. since low vitamin d status has been linked to many immune disorders, we designed this study to compare the vitamin d status in pv patients with healthy controls.in this case-control study, vitamin d status of 32 newly diagnosed pv patients was compared with 36 healthy control subjects. all patients were selected...

The word “pemphigus” is derived from the Greek term "pemphix” meaning bubble or blister. Pemphigus is a group of autoimmune diseases (see Table 4) characterized by intra-epithelial blistering, resulting in superficial vesicles or bullae that easily rupture, resulting in ulceration of mucosal and/or cutaneous sites. Although rare, pemphigus causes significant morbidity and potential mortality fo...

In this study a robust and simple classification into different stages of pemphigus, based on a set of therapeutic benchmarks including a definition of disease activity, is proposed. This staging method was validated against ELISA titres for autoantibodies against desmoglein-1 and -3. The proposed staging method was applied a priori to five newly diagnosed pemphigus patients in the course of th...

BACKGROUND Although corticosteroids have dramatically altered the prognosis of patients with pemphigus vulgaris, morbidity and mortality from systemic corticosteroid side-effects remains high. High-dose intravenous methylprednisolone has been used successfully in blistering diseases to avoid the complications of long-term orally-administered glucocorticoids. The objective of this study was to c...

pemphigus is a rare autoimmune blistering disease with different phenotypes. the evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. however, there is no gold standard to measure the disease activity in clinical trials. in this study we aimed to introduce the pemphigus vulgaris activity score (pvas) measurement and to assess the convergent validit...

Pemphigus vulgaris is an autoimmune bullous dermatosis presenting with flaccid blisters and erosions. The morphology of pemphigus reflects the more superficial intraepidermal level split seen histologically in contrast pemphigoid, where deep below epidermis. This a case 58-year-old male clinically arcuate tense bullae, which are characteristic pemphigoid group disorders, revealed tombstoning pa...

Background Some studies emphasise the relationship between herpes simplex virus (HSV) and pemphigus. Although possible role of HSV in pathogenesis pemphigus severity disease is obscure, we aimed to evaluate presence viruses (HSV 1/2) oral lesions patients with vulgaris also assess its association types lesions. Methods A retrospective study was conducted on collected data form collecting paraff...

BACKGROUND Pemphigus is a chronic autoimmune bullous disorder characterized by autoantibodies directed against desmoglein 3 and/or 1. Demonstration of intercellular deposition of IgG on the cell surface of keratinocytes by direct immunofluorescence (DIF) of the skin is the gold standard in the diagnosis of pemphigus. Recently, DIF of plucked hair demonstrating intercellular deposition of IgG in...

Pemphigus vulgaris (PV) is a chronic autoimmune bullous disease characterized by the formation of suprabasal cleavage and acantholysis. As this disease almost always affects the oral mucosa, conventional cytological smears of oral lesions can be used for the initial diagnosis of PV. We report two cases of PV that were initially diagnosed based on cytological smears of an oral sample. As atypica...