Studies from the 1960s indicated that increased microbial diversity and a succession in the predominant bacterial species in plaque correlate with the appearance of gingival inflammation and the development of periodontal disease. In the past few years, molecular characterization of the microflora found in various sites of the oral cavity of different subjects has detected around 700 bacterial ...

Filifactor alocis is a gram positive anaerobe that is emerging as an important periodontal pathogen. In the oral cavity F. alocis colonizes polymicrobial biofilm communities; however, little is known regarding the nature of the interactions between F. alocis and other oral biofilm bacteria. Here we investigate the community interactions of two strains of F. alocis with Streptococcus gordonii, F...

Metabolism of contraceptive compounds may be influenced by various drugs. Of clinical importance is induction by barbiturates, by diphenylhydantoin, and especially by rifampicin, of enzymes that are responsible for degradation of estrogens. The major target is the hepatic microsomal estrogen-2-hydroxylase (cytochrome P450 3A4). Another type of interaction of drugs with disposition and effective...

1Department of Dental Sciences, Faculty of Medicine, University of Liege, Liege, Belgium 2Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, National University Hospital, Singapore 3Department of Operative Dentistry and Endodontology, Dental School, Gent University, Belgium 4Laboratory of Lasers in Dentistry (LELO), Department of Restorative Dentistry, School of Dentistry, Univ...

INTRODUCTION Studies on bioavailability are part of the clinical development of drugs for oral use in order to identify potential drug-food interactions. For oral antitumor drugs, their clinical importance is currently recognized although regrettably the information available presents variability concerning the scientific evidence. OBJECTIVES To review the available scientific evidence about ...

Transcriptional profiling, bioinformatics, statistical and ontology tools were used to uncover and dissect genes and pathways of human gingival epithelial cells that are modulated upon interaction with the periodontal pathogens Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Consistent with their biological and clinical differences, the common core transcriptional response of...

The increased incidence of candida infections since the advent of antibiotic therapy is well known (Wolfson, 1949; Finland, 1951; Keefer, 1951; Woods et al., 1951; i'vIcVay and Sprunt, 1951; Editorial, J.A.M.A., 1951). We have found a rise also, over the past five years, in the incidence of Candida albicans in the mouths of healthy young adults. Using the same methods of sampling as in a previo...

Rosa Virginia Dutra de Oliveira, Cristiane Yumi Koga-Ito and Fernanda Lourençao Brighenti 1 UNESP, Department of Orthodontics and Pediatric Dentistry, Araraquara School of Dentistry, Univ Estadual Paulista/UNESP, Rua Humaitá, 1680, Centro, 14801-903, Araraquara, SP, Brazil 2 UNESP, Institute of Science and Technology, São José dos Campos, Univ Estadual Paulista/UNESP, Av. Eng. Francisco José Lo...

The majority of gene products that crowd a living cell interact, at least transiently, with other protein molecules. Concordantly, virtually all cellular events are mediated by protein-protein interactions (PPIs). The same applies to host-pathogen systems, where PPIs are essential in host colonization and infection. Some authors believe that the understanding of the human interactome will provi...