Oral cancers frequently contain DNA of human papillomavirus (HPV) type 16 or 18, but the functional significance of this is unclear. A role for HPV in the progression of oral cancer would be more plausible if the viral transforming genes were likely to be overexpressed in oral cancer cells. We therefore isolated and sequenced the long control region (LCR) of HPV-16 or HPV-18 from three oral can...

BACKGROUND The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer. METHODOLOGY AND PRINCIPAL FINDINGS Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non-cancer controls were ana...

Our meta-analysis was aimed to evaluate the association of CYP1A1 and glutathione-S-transferase M1 (GSTM1) polymorphisms with oral cancer susceptibility.The related articles were searched in PubMed, Embase, and CNKI databases. Fifty eligible studies were included in our meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the relationship of CYP1A1 (rs46469...

INTRODUCTION Oral cancer is a life-threatening disease. Lack of public awareness is a potent barrier for the early detection of oral cancer, especially for high-risk populations. OBJECTIVE This study aimed to determine the awareness and knowledge of the signs, symptoms and risk factors of oral cancer among a Siamese ethnic group in Tumpat, Kelantan. METHODS A cross-sectional study was condu...

O Ox xi id da an nt ts s a an nd d A An nt ti io ox xi id da an nt ts s i in n M Me ed di ic ca al l S Sc ci ie en nc ce e available at www.scopemed.org Abstract In the SouthEast Asian countries oral cancer is one among the commonly occurring malignancies due to tobacco use and quid chewing habits. Early stage diagnosis of the disease is reported to have a better prognosis. Sialochemistry studi...

Cancer is a disease of older adults, with 60% cancer diagnoses and 70% deaths occurring in individuals ≥ 65 years. Normal oral aging may transition to the presence one or more potential modifiers, such as new oncological diagnosis treatment. Oral conditions patients cause significant morbidity. Previous work suggests that are neither elicited/assessed/reassessed nor well-managed investigated pa...

BACKGROUND To determine the prevalence and clinicopathologic features of the oral cancer patients. MATERIAL AND METHODS Biopsy records of the participating institutions were reviewed for oral cancer cases diagnosed from 2005 to 2014. Demographic data and site of the lesions were collected. Sites of the lesion were subdivided into lip, tongue, floor of the mouth, gingiva, alveolar mucosa, pala...

The development of drugs that selectively kill oral cancer cells but are less harmful to normal cells still provide several challenges. In this study, the antioral cancer effects of tenuifolide B (TFB), extracted from the stem of the plant Cinnamomum tenuifolium are evaluated in terms of their effects on cancer cell viability, cell cycle analysis, apoptosis, oxidative stress, and DNA damage. Ce...

Downlo kground: Oral contraceptive formulations have changed over time, making it relevant to assess the of more recent formulations on breast cancer risk. In addition, some studies have found stronger posisociations of oral contraceptive use with estrogen receptor–negative (ER) than with ER-positive (ER) cancer. We carried out the first assessment of the effect of oral contraceptive use on the...

− New treatment approaches are needed to improve the effectiveness of oral cancer treatment, since surgical resection of the tumor in oral region causes various oral dysfunctions. The molecular biology of oral cancer has been progressively delineated. Concurrently, gene therapy techniques have been developed that allow targeting or replacement of dysfunctional genes in cancer cells, offering th...