introduction: oral manifestations can be the first signs of human immunodeficiency virus/acquired immunodeficiency syndrome (hiv/aids) and a useful marker for the progression of this disease. the present study aimed to determine the prevalence of oral manifestations and examine their relationship with socio-demographic factors in hiv-positive patients in the health centers affiliated to zahedan...

Cutaneous sensitization with a food antigen before its consumption elicits the development of food allergy. Here we report the site and stage dependent roles of basophils and pro-allergic cytokines, thymic stromal lymphopoietin (TSLP) and IL-33, in a mouse model of food allergy initially sensitized cutaneously with the food antigen. Mice are epicutaneously sensitized with the food antigen ovalb...

Background Milk allergy is the most common food allergy in infants and young children. Typical milk allergy symptoms involve hives, vomiting, or even anaphylaxis. For cow’s milk, strict avoidance is difficult because milk proteins are very ubiquitous. Oral immunotherapy (OIT) is an effective therapeutic option to induce milk oral tolerance. However, the immune mechanisms underlying this treatme...

A dog with Japanese cedar (Cryptomeria japonica, CJ) pollinosis had oral allergy syndrome (OAS) after ingesting fresh tomato. The dog showed specific IgE to both CJ and tomato allergens. As a negative control, twenty dogs without atopic dermatitis that had no exposure to tomato and no specific IgE to CJ allergen were used. They had no specific IgE to tomato allergen. Furthermore, IgE cross-reac...

Fish allergy is one of the most common food allergies in populations where fish is a major part of the diet. Most fish-allergic patients react to the panallergen parvalbumin present in multiple fish species. Our aim was to investigate the clinical case of a patient with oral allergy syndrome to pangasius and Nile tilapia but tolerance of other fish and seafood. The temporal relationship between...

Although the current standard care for patients with food allergy is based on avoidance of the trigger foods with hope of possible gain of tolerance, increasing number of studies have shown that oral immunotherapy is a promising approach. Understanding the transcutaneous sensitization and oral immune tolerance to food antigens has shifted focus of treatment and prevention. However, more studies...

OBJECTIVE To assess whether, on the basis of one blood test, penicillin allergy might be excluded sufficiently for general practitioners to give oral penicillin to patients claiming a history of penicillin allergy. DESIGN Prospective study of patients referred by general practitioners. SETTING Outpatient allergy clinic in a district general hospital. PATIENTS 175 referred patients who gav...

Background: Allergy to mollusks has been the focus of fewer studies than allergy to crustaceans. Furthermore, allergy to mollusks is less well characterized. Objectives: To describe the clinical characteristics of mollusk-allergic patients, to identify the responsible allergens, and to assess crossreactivity. Methods: We performed a prospective multicenter study including 45 patients with mollu...

Because progressively earlier presentations of food allergy implicate early environmental influences, there is intense interest in the prenatal factors inducing tolerogenic immune responses. Studies eliminating food allergens during pregnancy have failed to show reduction in the prevalence of long-term IgE-mediated food allergy in children, and recent data provides direct evidence supporting ea...