Metoprolol succinate (MS) gastroretentive (GR) controlled release system was formulated to increase gastric residence time leading to improved drug bioavailability. Box-Behnken model was followed using novel combinations of sodium alginate (SA), sodium carboxymethylcellulose (NaCMC), magnesium alumino metasilicate (MAS) as independent variables. Floating lag time (Flag), t25, t50, t75, diffusio...

We analyze the autocorrelations for the Local Hybrid Monte Carlo algorithm [1] in the context of free field theory. In this case this is just Adler’s overrelaxation algorithm [2]. We consider the algorithm with even/odd, lexicographic, and random updates, and show that its efficiency depends crucially on this ordering of sites when optimized for a given class of operators. In particular, we sho...

The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing domperidone as a model drug. Box-Behnken design was employed in formulating the GFDDS with three polymers: hydroxypropyl methylcellulose K4M (HPMC K4M) (X1), Carbopol 934P (X2) and sodium alginate (X3), as independent variables. Floating lag time (FLT), total floating time (TFT)...

An evolutionary algorithm for optimizing local control of chaos is presented. Based on a Lyapunov approach, a linear control law and the state-space region in which this control law is activated are determined. In addition, we study a relation between certain adjustable design parameters and a particular measure of the uncontrolled chaotic attractor in the state-space region of control (SSRC). ...

In this paper, we propose an efficient design of a reversible single precision floating point multiplier based on compressor. The single precision floating point multiplier requires the design of an efficient 24x24 bit integer multiplier. In the proposed architecture, the 24x24 bit multiplication operation is fragmented to nine parallel reversible 8x8 bit multiplication modules. In this paper, ...

In this paper, we build an estimator of the Hurst exponent of a fractional Lévy motion. The stochastic process is observed with random noise errors in the following framework: continuous time and discrete observation times. In both cases, we prove consistency of our wavelet type estimator. Moreover we perform some simulations in order to study numerically the asymptotic behaviour of this estimate.

We study the balance between the effect of spatial inhomogeneity of the potential in the dissipative term and the focusing nonlinearity. Sharp critical exponent results will be presented in the case of slow decaying potential.

We consider a passive scalar in a periodic shear flow perturbed by an additive fractional noise with the Hurst exponent H ∈ (0, 1). We establish a diffusive homogenization limit for the tracer when the Hurst exponent H ∈ (0, 1/2). We also identify an intermediate range of times when the tracer behaves diffusively even when H ∈ (1/2, 1). The proof is based on an auxiliary limit theorem for an ad...