The bacteria of the genus Borrelia are arthropod-borne spirochetes that cause relapsing fever and Lyme disease in humans. Like most arthropod-borne pathogens, Borreliae must survive in the periphery of their vertebrate hosts to allow for transmission to another arthropod vector. These spatial and temporal restrictions require that Borreliae evade the adaptive immune response. Borreliae have evo...

Considerable success has been made with many peptide antigen formulations, and peptide-based vaccines are emerging as the next generation of prophylactic and remedial immunotherapy. However, finding an optimal platform balancing all of the requirements for an effective, specific and safe immune response remains a major challenge for many infectious and chronic diseases. This review outlines how...

The traffic capacity of the highway toll plaza is studied in this paper. This model is based on M/M/c and M/G/K queuing system. The process of the vehicles pass through the toll plaza can be divided into two parts: entering system and departing system. Considering the reality that the highway traffic flow increases year by year, two models are proposed in this paper: (a) Find out the optimal nu...

the importance of the role played by bacteria in the pathogenesis of pulpal and apical disease has been established. one of the characteristics of apical periodontitis is apical bone resorption, which is due to apical immune response to bacterial infection. recently, novel bacterial complex lipid called phosphorylated dihydroceramides has been discovered to be of inflammatory activators. the ba...

it has been suggested that single nucleotide polymorphisms (snps) in genes involved in toll-like receptors (tlrs) pathway may exhibit broad effects on function of this network and might contribute to a range of human diseases. however, the extent to which these variations affect tlr signaling is not well understood. in this study, we adopted a bioinformatics approach to predict the consequences...

In most dynamic traffic congestion models, congestion tolls must vary continuously over time to achieve the full optimum. This is also the case in Vickrey's (1969) ‘bottleneck model’. To date, the closest approximations of this ideal in practice have so-called ‘step tolls’, in which the toll takes on different values over discrete time intervals, but is constant within each interval. Given the ...

With an increasing number of private toll road projects constructed or proposed in the U.S. through various forms of public private partnerships, and with more states removing legal constraints on the entry of private roads into the existing public road system, there are imperative needs to analyze the welfare and financial implications of utilizing private sector capitals in road financing for...

In most dynamic traffic congestion models, congestion tolls must vary continuously over time to achieve the full optimum. This is also the case in Vickrey's (1969) ‘bottleneck model’. To date, the closest approximations of this ideal in practice have so-called ‘step tolls’, in which the toll takes on different values over discrete time intervals, but is constant within each interval. Given the ...

BACKGROUND This study aimed to identify the emotional labor and workplace violence status among toll collectors by assessing and comparing the same with that in workers in other service occupation. It also aimed to analyze the relationship between emotional labor and workplace violence. METHODS This study examined emotional labor and workplace violence status in 264 female toll collectors fro...

A variety of cell recognition pathways affect neuronal target recognition. However, whether such pathways can converge at the level of a single growth cone is not well known. The RP3 motoneuron in Drosophila has previously been shown to respond to the muscle cell surface molecules TOLL and fasciclin III (FAS3), which are normally encountered during RP3 pathfinding in a sequential manner. TOLL a...