The standardisation of allergenic extracts in micrograms of the major allergen has encouraged the search for new treatment schedules, with the purpose of shortening the number of visits and doses required to reach the maintenance dose without eliciting a greater risk of adverse reactions for the patients. With this objective, a prospective multicentre pharmacovigilance study was designed that i...

background:  nowadays mri examinations have been widely used in clinical applications for many diagnoses. the use of contrast agent in mri improves lesion detection and characterization and causes more accurate diagnosis.  objectives: the aim of this study was comparing to optimal dose of magnevist contrast agent in modified t1w se (spin echo), t1w fse (fast spin echo) and t1w gre (gradient ech...

a. We recommend application of either topical agents or intraluminal lock solutions in reduction of exit-site infection and catheter-related bacteraemia. Options of topical agents include mupirocin 2% ointment, polysporin and medihoney. Intraluminal lock agents include both antibiotic based and non-antibiotic-based solutions. Ideal antibiotics and optimal doses are yet to be defined. (Level 1 e...

Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

The effects of bromocriptine and levodopa were compared in a blind trial in 18 patients with Parkinson's disease. Optimal doses of the two drugs were given in identical capsules: there was no significant difference between the therapeutic effects. There were wide individual differences in response to the two drugs. Side effects were more common with bromocriptine because of side effects.

This article presents an optimization of the drinking water treatment process at SUCRIVOIRE station. The objective is to optimize coagulation and flocculation (fundamental said plant)by determining optimal dosages products injected then proposes a program for calculating dose coagulant in order automatically determine latter according raw quality. contribution has advantage saving user from any...

To realize the full potential of promising new anticancer drugs, it is paramount importance to administer them at right dose. The aim this educational article provide several opportunities optimize drug dosing, focusing on oral targeted therapies. First, therapeutic monitoring can exposure in individual patients, if optimal concentration known. This approach particular interest regard kinase in...