Photoacoustic (PA) imaging is a hybrid biomedical imaging method that exploits both acoustical Epub ahead of print and optical properties and can provide both functional and structural information. Therefore, PA imaging can complement other imaging methods, such as ultrasound imaging, fluorescence imaging, optical coherence tomography, and multi-photon microscopy. This article reviews technique...

During the past decade, optical imaging combined with tomographic approaches has proved its potential in offering quantitative three-dimensional spatial maps of chromophore or fluorophore concentration in vivo. Due to its direct application in biology and biomedicine, diffuse optical tomography (DOT) and its fluorescence counterpart, fluorescence molecular tomography (FMT), have benefited from ...

The adoption of a short source-detector distance, combined with a time-resolved acquisition, can be advantageous in diffuse optical imaging due to the stricter spatial localization of the probing photons, provided that the strong burst of early photons is suppressed using a time-gated detection scheme. We propose a model for predicting the effect of the time-gated measurement system using a tim...

According to the industrial requirement for optical imaging, particularly in microscopic imaging, resolution improvement is one of the most important issues. In digital microscopic imaging, resolution of an optical system is limited by both optical parameters such as light wavelength and the objective lens numerical aperture and by spatial sampling such as pixel size of charge-coupled device ca...

IMAGING an object located in a highly scattering medium is a challenging problem with a wide range of applications in different fields: medicine, industry, defence and space. A better understanding of photon migration in turbid media has resulted in a surge of research interest in optical biomedical imaging. Limitations of X-ray imaging in detecting small lesions in tissues, in distinguishing m...

optical coherence tomography (oct) uses the spatial and temporal coherence properties of optical waves backscattered from a tissue sample to form an image. an inherent characteristic of coherent imaging is the presence of speckle noise. in this study we use a new ensemble framework which is a combination of several multi-layer perceptron (mlp) neural networks to denoise oct images. the noise is...

A multi-modal optical imaging system for quantitative 3D bioluminescence and functional diffuse imaging is presented, which has no moving parts and uses mirrors to provide multi-view tomographic data for image reconstruction. It is demonstrated that through the use of trans-illuminated spectral near infrared measurements and spectrally constrained tomographic reconstruction, recovered concentra...