BACKGROUND The combined use of free and total prostate-specific antigen (PSA) in early detection of prostate cancer has been controversial. This article systematically evaluates the discriminating capacity of a large number of combination tests. METHODS Free and total PSA were analyzed in stored serum samples taken prior to diagnosis in 429 cases and 1,640 controls from the Physicians' Health...

The area under the receiver operating characteristic curve is the most commonly used measure of the ability of a biomarker to distinguish between two populations. Some markers are subject to substantial measurement error. Under normality assumptions, the authors develop a confidence interval procedure for the area under the receiver operating characteristic curve that adjusts for measurement er...

A portable, depth-sensitive clinical spectroscopy device for noninvasive early diagnosis of oral cancer is described. We carried out a pilot study to evaluate the ability of the device to identify oral neoplasia using a previously developed diagnostic algorithm. A total of 79 oral sites in 33 subjects, including 28 patients with oral lesions and 5 healthy volunteers, were measured and analyzed....

Performance evaluation of any classification method is fundamental to its acceptance in practice. Evaluation should consider the dependence of a classifier’s accuracy on relevant covariates in addition to its overall accuracy. When developing a classifier with a continuous output that allocates units into one of two groups, receiver operating characteristic (ROC) curve analysis is appropriate. ...

The aims of the present study were to evaluate the predictive value of the platelet-to-lymphocyte ratio for peritoneal metastasis in patients with gastric cancer and to construct an available preoperative prediction system for peritoneal metastasis. A total of 1080 patients with gastric cancer were enrolled in our study. The preoperative platelet-to-lymphocyte ratio and other serum markers and ...

Received Jun 5, 2016 Revised Aug 8, 2016 Accepted August 24, 2016 Receiver operating characteristic (ROC) curve is an important technique for organizing classifiers and visualizing their performance in tactical systems in the presence of jamming signal. ROC curves are commonly used to evaluate the performance of classifiers for anomalies detection. This paper gives a survey of ROC analysis base...

Receiver operating characteristic (ROC) curve is widely applied in measuring discriminatory ability of diagnostic or prognostic tests. This makes ROC analysis one of the most active research areas in medical statistics. Many parametric and semiparametric estimation methods have been proposed for estimating the ROC curve and its functionals. In this paper, we propose a fully nonparametric Bayesi...

background identification of a normal range for biomarkers, based on pregnancy outcomes (caused by their high or low values) is of special importance in clinical studies. as some pregnancy outcomes can happen in both high and low levels of biomarkers, the receiver-operating characteristic (roc) curve is unsuitable for identifying these levels separately; rather, a statistical method is preferab...