The recent large decrease in splenectomy use for chronic immune thrombocytopenia (ITP) is partly due to still-unsolved questions about long-term safety. We performed the first single-center exposed/unexposed cohort study evaluating the long-term incidence of splenectomy complications in patients with primary ITP. Overall, 83 patients who underwent splenectomy more than 10 years ago (exposed) we...

Background: No evidence of the possibility to alter a constituent immune system without directly affecting one its associated components has been shown yet. Methods: A schematic model was developed in which two triggers, fasting and splenectomy, were studied for their ability affect expression cell membrane epitopes cytokine secret...

We present the case of a 34-year-old female patient with severe pulmonary hypertension diagnosed > 15 years after splenectomy to emphasize need monitor patients for development chronic thromboembolic (CTEPH). The lack screening tests this group patients, as in described case, resulted serious clinical condition at time diagnosis. Without specialized treatment, probability her survival 5 was onl...

Some hematological diseases can benefit from splenectomy for either diagnosis or treatment. When dealing with patients with thalassemia, splenectomy is a common therapeutic option, particularly indicated when the patient has increased transfusion demand, symptomatic splenomegaly or any signs of poor health, leucopenia, and thrombocytopenia.1 However, splenectomy can lead to thromboembolic event...

bocytopenia), splenectomy will not result in clinically significant improvement. However, it is possible that for certain individuals a small change in circulating platelet number may improve hemostasis. For example, affected males with GATA1 mutations in one family reported diminished frequency and severity of bleeding episodes in adulthood after splenectomy despite persistent thrombocytopenia...

Splenic injuries are amongst the most frequent trauma-related which requires emergency surgeries demanding meticulous surgical and anesthetic management. The aim while managing splenic trauma patients, is to restore homeostasis normal pathophysiology in body by achieving hemostasis with an splenectomy. To date, there have been few reports describing anaesthetic management of COVID-19 patients p...

Splenectomy is the only treatment of ITP known to have "curative" effects in a substantial fraction of patients. However, the true long-term outcome is uncertain and controversial because published series have not adjusted for the duration of follow-up. This IRB-approved retrospective study included all patients with ITP who underwent splenectomy between 1988-1993 at three major medical centers...