Article published in the journal Correio da Manha, issue dated of July 30th, 1929, page 1. The present version has had orthographic updates and was caulked two fragments missing original, both indicated brackets.

On behalf of the SIM Executive Board and our Chapter Leaders, we are very pleased to have established an alliance with MISQE that provides benefit to our members as well as the IT profession. SIM is a community of thought leaders with a mission to share experiences and rich intellectual capital that can be applied in our profession. This matches very well with the mission of MISQE to provide in...

One of the important standards for document interchange and representation that has emerged is SGML, the Standard Generalized Markup Language. SGML is designed to capture the logical structure of documents, i.e. the logical components such as titles and paragraphs and their interrelationships. SGML is a complex standard, and the design of a database system for managing SGML documents poses many...

the solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. fused dispersions (fds) of simvastatin (sim) using peo-ppo block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. the accumulative solub...

We study possible interrelations between the 300 year record of the yearly sunspot numbers and the solar inertial motion (SIM) using the recently developed technique of synchronization analysis. Phase synchronization of the sunspot cycle and the SIM is found and statistically confirmed in three epochs (1734–1790, 1855–1875 and 1907–1960) of the whole period 1700–2000. These results give quantit...

The spitz class genes, pointed (pnt), rhomboid frho), single-minded (sim), spitz (spi)and Star (S), as well as the Drosophila epidermal growth factor receptor (Egfr) signaling genes, argos (aos), Egfr, orthodenticle (otd) and vein (vn), are required for the proper establishment of ventral neuroectodermal cell fate. The roles of the CNS midline cells, spitz class and Egfr signaling genes in cell...

OBJECTIVE To analyze the contribution of linkage between databases of live births and infant mortality to improve the completeness of the variables common to the Mortality Information System (SIM) and the Live Birth Information System (SINASC) in Brazilian capitals in 2012. METHODS We studied 9,001 deaths of children under one year registered in the SIM in 2012 and 1,424,691 live births prese...

A new gas chromatography/mass spectrometry (GC/MS) method is proffered for the analysis of polycyclic aromatic hydrocarbons (PAH) and their alkylated homologs in complex samples. Recent work elucidated the fragmentation pathways of alkylated PAH, concluding that multiple fragmentation patterns per homolog (MFPPH) are needed to correctly identify all isomers. Programming the MS in selected ion m...

Lung cancer is the most common cause of cancer-related death. Nonetheless, a decrease in overall incidence and mortality has been observed in the last 30 years due to prevention strategies and improvements in the use of chemotherapeutic agents. In recent studies, Simvastatin (SIM) has demonstrated anti-tumor activity, as well as potent chemopreventive action. As an inhibitor of 3-hydroxy-3-meth...