Halothane and propofol enhance the activity of the -aminobutyric acid (GABA) system, which is one of the most important systems in the mechanism of anesthesia. To determine whether halothane and propofol enhance GABAergic responses by the same mechanism, we performed single-channel patch-clamp experiments with rat cortical neurons in primary culture. Each of the open-time and closed-time distri...

Currents through single potassium channels were studied in cell-attached or inside-out patches from collagenase-dispersed smooth muscle cells of the guinea pig taenia coli. Under conditions mimicking the physiological state with [K+]i = 135 mM: [K+]o = 5.4 mM, three distinct types of K+ channel were identified with conductances around 0 mV of 147, 94, and 63 pS. The activities of the 94- and 63...

We have studied the effects of clinically useful anthraquinones on the cardiac sarcoplasmic reticulum calcium-release channel. Micromolar concentrations of doxorubicin and other anthracyclines at the cytosolic face of the channel significantly and reversibly increase the open probability of single channels in artificial phospholipid bilayers. Lifetime analysis shows that anthracyclines and calc...

Diazepam and (--)-pentobarbital each potentiate the increase in chloride ion conductance produced by gamma-aminobutyric acid (GABA) i voltage-clamped mouse spinal neurons grown in culture. Fluctuation analysis was used to compare the properties of elementary ion-channel events underlying the chloride conductance produced by GABA alone and during potentiation by the two drugs. Neither drug alter...

Open channel fluid flow principles are applied to understand how helium might behave in the event of a release or spill in a long tunnel enclosure. An example would be helium flowing along the Tevatron accelerator tunnel as a result of some rupture of a header system. Buoyant forces would drive the helium along the ceiling until a vent to atmosphere is reached. An analogy is water flowing up to...

− Reported here are some results obtained, from a calculus algorithm application that, based on known equation analytical solutions of water flow profiles, allows the study of steady-state, gradually varied flow in open channel networks. The procedure allows to calculate, in the case of slow water flow into gradually downward slope channels, in the direction of motion, the florates and water le...

A finite-dimensional Port-Hamiltonian formulation for the dynamics of smooth open channel flows is presented. A numerical scheme based on this formulation is developed for both the linear and nonlinear shallow water equations. The scheme is verified against exact solutions and has the advantage of conservation of mass and energy to the discrete level.