Mitochondria are physically and biochemically in contact with other organelles including the endoplasmic reticulum (ER). Such contacts are formed between mitochondria-associated ER membranes (MAM), specialized subregions of ER, and the outer mitochondrial membrane (OMM). We have previously shown increased expression of MAM-associated proteins and enhanced ER to mitochondria Ca(2+) transfer from...

Automatic generation of built-in contract testers that check pairwise interactions between client and server components is presented. Test artifacts are added to development models, i.e., these models are refined towards testing. The refinement is specified by a set of ATL transformation rules that are automatically performed by the ATL-DT tool. We focus on the KobrA development methodology and...

In this paper we present a new gesture based control for snake robot using a custom developed accelerometer based data glove. This Snake robot which was biologically inspired was developed for the purpose of search and rescue and serve as a research platform for its locomotion analysis. The locomotion of Snakes is because a differential curve traveling in its body from the head to the tail and ...

Primer E very day, a healthy human loses billions of cells by design [1]. Cell death processes, such as apoptosis and other tightly regulated mechanisms that kill old, damaged, or unwanted cells, are critically important for normal embryonic development and for the maintenance of physiological functions in multicellular organisms (and likely in unicellular species as well) [1,2]. Insufficient o...

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Abstract Objectives According to the core Buddhist psychology models of “two arrows pain” and “co-dependent origination,” pain is resultant bodily mental factors, which can be regulated by meditation states traits. Here we investigated how related aversion identification (self-involvement) experiences are modulated focused attention (FAM), open monitoring (OMM), loving kindness (LKM), as well e...

Loss-of-function mutations in PINK1 and Parkin cause early onset Parkinson’s disease (Kitada et al., 1998; Valente et al., 2004). Genetic studies in Drosophila and cell biology studies in mammalian cells place PINK1 upstream of Parkin in the same pathway and indicate they may normally mediate mitochondrial quality control (Narendra et al., 2012; Ashrafi and Schwarz, 2013; Winklhofer, 2014). PIN...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 205 No. 2 179–195 www.jcb.org/cgi/doi/10.1083/jcb.201312066 JCB 179 Correspondence to György Hajnóczky: [email protected] Abbreviations used in this paper: 2P, two photon; ADOA, autosomal-dominant optical atrophy; CRU, Ca2+ release unit; CSMDH, Ca2+-sensitive mitochondrial matrix dehydrogenase; EC, excitation–contraction; E...