Male rats and male mice received a single 2-hr exposure to 0 (control), 10, or 30 ppm of methyl isocyanate and were sacrificed after 1, 3, 14, or 90 days to assess the ultrastructural changes in the nasal mucosa by transmission electron microscopy. One day after exposure to methyl isocyanate, there were widespread areas of necrosis and degeneration of the respiratory and olfactory epithelium of...

When the results of the standard olfactory acuity test assigned to about 8,000 patients with dysosmia, who visited our olfactory outpatient clinic of the Department of Otorhinolaryngology of Showa University Hospital, were analyzed, it was found that a difference in olfactory acuity loss between recognition threshold and detection threshold was over 1.0 in many of them. Since normal Subjects sh...

The olfactory system senses odors, but not exclusively, as shown over the past years. It also registers other modalities such as temperature and pressure. However, it remains unknown how widespread these sensitivities are across species and how strongly their processing is interconnected with the processing of odors. Here, we present data on the β-glomerulus in the olfactory bulb of Xenopus lae...

Although rhesus monkeys have been generally regarded as refractory to infection with poliomyelitis virus administered by the oral route, two of seven infant rhesus developed paralytic poliomyelitis when fed murine-adapted strains of virus. Preliminary intranasal treatment with zinc sulfate and negative serial sections of the olfactory bulbs of the positive animals ruled out the possibility that...

Olfactory disorders are one of the characteristic symptoms coronavirus disease 2019 (COVID-19), which causes infection and inflammation upper lower respiratory tract. To our knowledge, there no treatments for COVID-19-related olfactory disorder. Here, we report five disorder cases in COVID-19, treated using Japanese traditional (Kampo) medicine, kakkontokasenkyushin’i. We patients with mild COV...

SIR, in the recent paper by Gudziol et al. (2009), treatment of chronic rhinosinusitis lead to an increase of the olfactory bulb volume over a 3-month period, and they concluded that this was due to the restoration of olfactory function. In this letter, we point out another factor that may affect olfactory bulb volume: neuroinflammation regulated neurogenesis. The olfactory bulb volume is great...

Mammalian olfactory sensory neurons (OSNs) form the primary elements of the olfactory system. Inserted in the olfactory mucosa lining of the nasal cavity, they are exposed to the environment and their lifespan is brief. Several reports say that OSNs are regularly regenerated during the entire life and that odorant environment affects the olfactory epithelium. However, little is known about the ...

Studies of the two major olfactory organs of rodents, the olfactory mucosa (OM) and the vomeronasal organ (VNO), unraveled the molecular basis of smell in vertebrates. However, some vertebrates lack a VNO. Here we generated and analyzed the olfactory transcriptome of the zebrafish and compared it to the olfactory transcriptomes of mouse to investigate the evolutionary and molecular relationship...

The morphoanatomy, cellular organization, and surface architecture of the olfactory apparatus in Cirrhinus reba (Hamilton) is described using light and scanning electron microscopy. The oval shaped olfactory rosette contained 32 ± 2 primary lamellae on each side of the median raphe, and was lodged on the floor of the olfactory chamber. The olfactory lamellae were basically flat and compactly ar...