PURPOSE Lamina cribrosa (LC) morphology could be implicated in the progression of glaucoma. To date, no established, quantifiable parameter to assess LC shape in vivo exists. We aim to introduce a new global shape index for the anterior LC (LC-GSI) and to identify associations with ocular factors in a healthy Indian population. METHODS Optical coherence tomography (OCT) scans of the optic ner...

PURPOSE To investigate relationships between acute intraocular pressure (IOP)-induced optic nerve head surface deformation and corneal hysteresis and thickness in glaucomatous and nonglaucomatous human eyes. METHODS This was a prospective experimental study of 100 subjects (38 with glaucoma, 62 without glaucoma). Data collected included spherical equivalent, optic disc diameter, central corne...

Colchicine has been reported to destroy ganglion cells (GCs) in the retina of hatchling chicks. We tested whether colchicine influences normal ocular growth and form-deprivation myopia, and whether it affects cells other than GCs. Colchicine greatly increased axial length, equatorial diameter, eye weight, and myopic refractive error, while reducing corneal curvature. Colchicine caused DNA fragm...

PURPOSE To evaluate possible seasonal variations in myopia progression and ocular elongation in school children. METHODS Seventy-one children who were enrolled in a clinical trial of bifocals were examined every 6 months for 30 months. Three 6-month intervals ("winters") included none of the summer vacation from school, and two intervals ("summers") included all of the summer vacation. Myopia...

Objective: This study aimed to explore the influence of premature birth and mild retinopathy of prematurity (ROP) on the refractive status and the development of ocular optical components. Methods: The preterm infants who received fundus screening were divided into ROP group and non-ROP group. In addition, age matched term infants were also recruited. Results: The incidence of myopia was the hi...

PURPOSE To profile accommodative biometric changes longitudinally and to determine the influence of age-related ocular structural changes on the accommodative response prior to the onset of presbyopia. METHODS Twenty participants (aged 34-41 years) were reviewed at six-monthly intervals over two and a half years. At each visit, ocular biometry was measured with the LenStar biometer (www.Haag-...

PURPOSE To compare the individual means of ocular components of both eyes in patients with anisometropia; to correlate the differences of the components with refractive differences; and to identify the smallest number of factors that contain the same level of information expressed in the set of variables that influence refractive difference. METHODS An analytical transversal study was carried...

PURPOSE The purpose of this study was to determine if genetic variants in the hepatocyte growth factor receptor (MET) gene are associated with refractive error and ocular biometric measures in a Caucasian cohort. METHODS A case-control association study using 818 Caucasian adults (37.2% male, 62.8% female; average age: 51.21+/-17.17 years) was undertaken. All individuals were genotyped for 16...

PURPOSE To compare choroidal thickness measurements among normal eyes, eyes with normal tension glaucoma (NTG), and those with primary open-angle glaucoma (POAG), and to correlate choroidal thickness with demographic and clinical ocular parameters. METHODS Choroidal thickness was measured with enhanced depth-imaging (EDI) optical coherence tomography (OCT) in one eye of 38 normal, 20 NTG, and...