introduction the global initiative for Chronic obstructive lung disease (gold) recently published an updated 2016 edition of the global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease (Copd)1 the aim of the document is to guide healthcare professionals in the diagnosis and management thereof and to differentiate patients with Copd from those with a...

Acute exposure to selenium hydrochloride resulted in severe dyspnea and a pneumomediastinum in a young healthy man. Pulmonary function tests revealed restrictive and obstructive airways disease. Although the patient's pulmonary function slowly improved, subsequent studies revealed persistent impairment. Therefore, exposure to selenium gas may result acutely in severe coughing and wheezing and m...

Accordingly, it would also be interesting to have answers to the following questions concerning Global Initiative for Chronic Obstructive Lung Disease stage IV chronic obstructive pulmonary disease patients. 1) How many patients with a ground-level arterial oxygen saturation measured by pulse oximetry of .95% underwent hypoxic challenge testing? 2) How many patients flew without oxygen and with...

BACKGROUND Negative pressure ventilation provides intermittent non-invasive ventilatory assistance for patients with advanced chronic obstructive lung disease. Upper airway obstruction during sleep, a reported complication of the technique, may, however, limit its clinical applicability. METHODS The effects of nocturnal negative pressure ventilation on ventilation and on indices of sleep qual...

Chronic obstructive pulmonary disease is characterised by oxidative stress, but little is known about the associations between antioxidant status and all-cause mortality in adults with this disease. The objective of the present study was to examine the prospective associations between concentrations of α- and β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene, Se, vitamin C and α-tocopher...

OBJECTIVE To report on the proportions of restrictive, obstructive and combined types of respiratory diseases in patients referred to respiratory units at the Korle Bu Teaching Hospital. METHOD This was a retrospective study of lung function test (LFT) data on patients who were referred from clinics both in and outside KBTH. A spirometer was used to assess various lung volume parameters. RE...

Chronic obstructive pulmonary disease (COPD) is an obstructive lung disease often caused by cigarette smoke, and characterised by inflammation and abnormalities of the large and small airways (i.e. those with an internal diameter <2 mm), as well as by alveolar destruction (emphysema). Recent evidence suggests that small airway disease precedes emphysema [1] and, therefore, it may be useful to i...

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has defined stage I chronic obstructive pulmonary disease (COPD) as forced expiratory volume in one second/forced vital capacity (FEV1/FVC)% <70% and a FEV1% predicted of >80%. Stage 2 has been defined as FEV1/FVC <70% and a FEV1% pred of <80%. The authors examined the extent of COPD misdiagnosis using this definition in healthy,...

Chronic obstructive lung disease is characterized by persistent abnormalities in epithelial and immune cell function that are driven, at least in part, by infection. Analysis of parainfluenza virus infection in mice revealed an unexpected role for innate immune cells in IL-13-dependent chronic lung disease, but the upstream driver for the immune axis in this model and in humans with similar dis...

Zielsetzung Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of death worldwide, yet early detection and treatment can prevent the progression disease. X-ray Computed Tomography (CT) scans chest provide quantitative measure morphological changes in lung. The potential incorporating optimal Window Setting (WS) selection, typically carried out during examination CT for COPD, genera...