uch attention has been paid to proteinuria and renal dysfunction in obese people without diabetes mellitus (DM) as obesity-related glomerulopathy (ORG). The Adults Treatment Panel III (ATP) of the National Cholesterol Education Program, based on data in the United States, defined obesity as a body mass index (BMI) of ≥30 kg/m; however, the Japan Society for the Study of Obesity reported that ob...

With improvements of surgical techniques and peri-operative care, survival of liver transplant patients has continuously improved over the last decades. Unfortunately, this trend is accompanied by a growing incidence of chronic renal failure. Also, due to the introduction of the MELD system, a large proportion of patients present with some degree of renal dysfunction prior to transplantation, w...

Obesity and hypertension are risk factors for the development of chronic kidney disease. The mechanisms by which elevated blood pressure and fatty acids lead to the development of renal injury are incompletely understood. Here, we investigated the contributions of cholesterol and oxidative stress to renal endothelial dysfunction and glomerular injury in a model of obesity and hypertension. Male...

Hepatitis C infection is a leading etiology of hepatic dysfunction and major indication for liver transplantation due to the development fibrosis, cirrhosis, hepatocellular carcinoma. Nonalcoholic fatty disease (NAFLD) and, specifically, its subtype nonalcoholic steatohepatitis (NASH) rising cause disease. It predicted surpass hepatitis as transplant. The introduction direct-acting antivirals (...

background: numerous studies have now demonstrated that heart failure with a normal ejection fraction (hfnlef) is common. hypertension is also the most commonly associated cardiac condition in patients with hfnlef. despite the observed link between microalbuminuria, obesity, and cardiovascular disorders, this question has remained ― ‘which is more important for the prediction and prevention of ...