Jay C. Erickson et al. (1) describe the energy intake and energy expenditure of mutant obese mice (ob/ob) in which the gene for neuropeptide Y (NPY) is disrupted. They conclude that deficiency of NPY in the ob/ob mouse reduces the elevated food intake and increases the low energy expenditure, partially ameliorating the obesity. Another report, by Mary Ann Pelleymounter et al. (2), describes ene...

All pipelines are subject to corrosion and require inspection in accordance with regulatory requirements to ensure human safety. Intelligent Pipeline Inspection Gauges (PIGs) as shown in Figure 1 have provided reliable on-line inspection of pipelines for many years, supplying operators with detailed information about pipeline condition. The average transmission pipe length is 300km and the aver...

OBJECTIVE Hepatic steatosis is strongly associated with insulin resistance, but a causal role has not been established. In ob/ob mice, sterol regulatory element binding protein 1 (SREBP1) mediates the induction of steatosis by upregulating target genes, including glycerol-3-phosphate acyltransferase-1 (Gpat1), which catalyzes the first and committed step in the pathway of glycerolipid synthesis...

In order to examine the influence of obesity on metabolic disorder and liver pathogenesis of the Fatty Liver Shionogi (FLS) mouse, which develops hereditary fatty liver and spontaneous liver tumors, we established a new congenic strain named FLS-Lep(ob). The Lep(ob) gene of the C57BL/6JWakShi (B6)-Lep(ob)/Lep(ob) mouse was transferred into the genome of the FLS mouse, by backcross mating. FLS-L...

The hypothalamic peptide melanin-concentrating hormone (MCH) plays important roles in energy homeostasis. Animals overexpressing MCH develop hyperphagia, obesity, and insulin resistance. In this study, mice lacking both the MCH receptor-1 (MCHr1 knockout) and leptin (ob/ob) double-null mice (MCHr1 knockout ob/ob) were generated to investigate whether the obesity and/or the insulin resistance li...

of the Thesis DCT Based SPIHT Architecture for Hyperspectral Image Data Compression by Jieming Xu Master of Science in Electrical and Computer Engineering Northeastern University, August 2016 Prof. Vinay K. Ingle, Adviser The wavelet transformation is leading and widely used technology in transform coding. Many coding algorithms are designed for this transformation based on its unique structure...

Introduction: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease. In the present study, we investigated the response of subventricular zone (SVZ) adult stem cells in the experimental autoimmune encephalomyelitis (EAE), an animal model of MS, and also the differentiation fate of these stem cells. Methods: Mice were immunized with MOG peptide emulsified in complete Freund'...

Obese leptin-deficient ob/ob mice exhibit a low-grade chronic inflammation together with a low muscle mass. Our aim was to analyze the changes in muscle expression levels of genes related to oxidative stress and inflammatory responses in leptin deficiency and to identify the effect of in vivo leptin administration. Ob/ob mice were divided in three groups as follows: control ob/ob, leptin-treate...