Sulfonic acid functionalized SBA-15 as a nanoporous acid catalyst was used in the synthesis of 2-Aryl benzoxazoles 4 by the condensation of 2-aminophenol 1 and benzoyl chlorides 2 under microwave irradiation in solvent free reaction conditions. The advantages of this methodology are good product yields (60-98%), being environmentally benign, short reaction times and easy work up.

Autoxidation of para-aminophenol (PAP) has been proposed to account for the selective nephrotoxicity of this compound. However, other studies suggest that hepatic metabolites of PAP rather than the parent compound may be responsible for renal damage. These studies were designed to investigate PAP metabolism in isolated hepatocytes. We synthesized several proposed metabolites for analysis by HPL...

It has been demonstrated by many workers (l-5) that phenols may be conjugated with glucuronic acid or inorganic sulfate in vitro by liver slices and by cell-free preparations. By using a system developed in this laboratory, together with a modification of the analytical procedure described by Levvy and Storey (3), the synthesis of the conjugated sulfate, and possibly of the glucuronide, has bee...

An arylamine N-acetyltransferase (NAT) responsible for the N acetylation of exogenous 3-amino-4-hydroxybenzoic acid in Streptomyces griseus was identified and characterized. This enzyme was distinct from other eukaryotic and bacterial NATs in that it acetylated various 2-aminophenol derivatives more effectively than it acetylated 5-aminosalicylic acid, and thus it may be involved in the metabol...

A new phenylpropanoid glycoside (1), and two new coumarin glycosides (2, 3), together with two known compounds (4, 5), have been isolated from the stems of Hydrangea paniculata Sieb. Their structures have been determined by spectroscopic and chemical methods. Furthermore, compound 1 (50 μM) exhibited significant hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell ...

A nitridoosmium(VI) complex [Os(VI)(N)(sap)(OH(2))Cl] (H(2)sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5'-guanosine monophosphate.

We describe here the ability of manganese oxide monosheets to aggregate to form layered structures with 4-aminophenol molecules. These aggregated monosheets could be considered as the first step to synthesize a self-assembled layered hybrid of phenol-manganese ions with phenol and manganese(III) and (IV) as exists in the water oxidizing complex of Photosystem II.

Nitrogen-containing ordered mesoporous carbon (NOMC) was synthesized by using m-aminophenol (MAP) as a carbon and nitrogen co-precursor via a co-assembly process with F127 in aqueous phase and exhibited a good catalytic performance for selective oxidation of ethylbenzene.

Using alkaline pH adjustment, the reaction between graphene oxide and L-ascorbic acid led to the formation of a carbocatalyst film with numerous graphene edges protruding out of basal planes, which had a markedly enhanced carbocatalytic activity for conversion of 4-nitrophenol to 4-aminophenol, as compared to that of the carbocatalyst counterpart without involving pH mediation.