Abstract The aim was to study the dependence of single-nucleotide polymorphism CSN3 gene on amino acid and mineral composition milk Holstein cows. object research is cows (n=100; age - 4-5 years). elemental estimated according 25 chemical elements (Al, As, B, Ca, Cd, Co, Cr, Cu, Fe, I, K, Li, Mg, Mn, Na, Ni, P, Pb, Se, Si, Sn, Hg, Sr, V, Zn) by ICP AES MS. (arginine, tyrosine, phenylalanine, hi...