نتایج جستجو برای: nucleocytoplasmic shuttling
تعداد نتایج: 4663 فیلتر نتایج به سال:
WD repeat-containing protein 42A (WDR42A) is a member of the WD40-repeat proteins. Here, we investigated the localization pattern of WDR42A in living cells. By mutational analysis, a nuclear localization signal, 114PRRRVQRKR122, was for the first time determined. The dominant negative, co-immunoprecipitation and GST pull-down results further demonstrated that the nuclear import of WDR42A was me...
1 pMad Local Model In our analysis, transmission of BMP signal from membrane to nucleus through Smad phosphorylation is approximated by Eq. 1. More detailed networks on nucleocytoplasmic shuttling of Smad and their downstream interpretations are given in (1). The Smad network model we consider here for signal transduction is represented using a 1 order differential equation, that includes phosp...
The decapping scavenger enzyme DcpS is known for its role in hydrolyzing the cap structure following mRNA degradation. Recently, we discovered a new function in miRNA degradation activation for the ortholog of DcpS in C. elegans. Here we show that human DcpS conserves its role in miRNA turnover. In human cells, DcpS is a nucleocytoplasmic shuttling protein that activates miRNA degradation indep...
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