نتایج جستجو برای: nuclear factor κb nf κb

تعداد نتایج: 1059579  

2015
Wanda M. Snow Payam S. Pahlavan Jelena Djordjevic Danielle McAllister Eric E. Platt Shoug Alashmali Michael J. Bernstein Miyoung Suh Benedict C. Albensi

Research has identified several transcription factors that regulate activity-dependent plasticity and memory, with cAMP-response element binding protein (CREB) being the most well-studied. In neurons, CREB activation is influenced by the transcription factor nuclear factor kappa B (NF-κB), considered central to immunity but more recently implicated in memory. The transcription factor early grow...

2016
Viktor Brabec Jana Kasparkova Hana Kostrhunova Nicholas P. Farrell

Nuclear DNA is the target responsible for anticancer activity of platinum anticancer drugs. Their activity is mediated by altered signals related to programmed cell death and the activation of various signaling pathways. An example is activation of nuclear factor kappaB (NF-κB). Binding of NF-κB proteins to their consensus sequences in DNA (κB sites) is the key biochemical activity responsible ...

Journal: :Journal of virology 2011
Katharine Fagan-Garcia Michele Barry

The classical nuclear factor kappa B (NF-κB) signaling pathway is an important regulator of inflammation and innate immunity that is activated by a wide variety of stimuli, including virus infection, tumor necrosis factor alpha (TNF-α), and interleukin 1β (IL-1β). Poxviruses, including vaccinia virus (VV) and ectromelia virus, encode multiple proteins that function in immune evasion. Recently, ...

Journal: :The European respiratory journal 2011
P Seidel M Roth Q Ge I Merfort C T S'ng A J Ammit

Airway smooth muscle cells (ASMCs) secrete eotaxin and RANTES (regulated on activation, normal T-cell expressed and secreted) in response to tumour necrosis factor (TNF)-α, which is inhibited by the nuclear factor (NF)-κB inhibitor dimethylfumarate (DMF). NF-κB/IκB (inhibitor of NF-κB) glutathionylation and changes in chromatin remodelling can inhibit NF-κB activity. In this study, we determine...

Journal: :Acta biochimica et biophysica Sinica 2013
Weikang Guo Dongliang Zhang Liyan Wang Yu Zhang Wenhu Liu

Asymmetric dimethylarginine (ADMA) activates nuclear factor (NF)-κB in endothelial cells, while actin-stabilizing or -destabilizing drugs prevent ADMA-induced activation of NF-κB. Here we investigated how actin-targeting drugs regulated ADMA-induced NF-κB activation in endothelial cells. Human umbilical vein endothelial cells were treated with ADMA for 24 h in the absence and presence of cytoch...

Journal: :The Journal of pharmacology and experimental therapeutics 2016
Victor Garcia Brian Shkolnik Laura Milhau John R Falck Michal Laniado Schwartzman

Increased vascular 20-hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 arachidonic acid metabolite, promotes vascular dysfunction, injury, and hypertension that is dependent, in part, on the renin angiotensin system (RAS). We have shown that, in human microvascular endothelial cells, 20-HETE increases angiotensin-converting enzyme (ACE) mRNA, protein, and ACE activity via an epidermal ...

2012
Hong Ri Jin Song Zhu Jin Xing Fu Cai Donghao Li Xue Wu Ji Xing Nan Jung Joon Lee Xuejun Jin

BACKGROUND Cryptopleurine, a phenanthroquinolizidine alkaloid, was known to exhibit anticancer activity; however, the underlying mechanism is poorly understood. Because the nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, and development and progression of cancer, we investigated the effects of cryptopleurine on tumor necrosi...

2016
Qingshi Liu Zhenfeng Zhang Zhenhua Zheng Caishang Zheng Yan Liu Qinxue Hu Xianliang Ke Hanzhong Wang

Human bocavirus (HBoV), a parvovirus, is a single-stranded DNA etiologic agent causing lower respiratory tract infections in young children worldwide. Nuclear factor kappa B (NF-κB) transcription factors play crucial roles in clearance of invading viruses through activation of many physiological processes. Previous investigation showed that HBoV infection could significantly upregulate the leve...

2012
Ming-Xian Yan Hong-Bo Ren Yi Kou Min Meng Yan-Qing Li

BACKGROUND/AIMS High-fat diets contribute to pancreatic fibrogenesis, but the pathogenesis remains unclear. This study investigated the role of nuclear factor kappa B (NF-κB) in high-fat diet-induced pancreatic fibrosis in rats. METHODS Male Wistar rats were fed a high-fat diet or standard normal chow for 20 weeks. Pancreatic fibrosis was determined by Sirius red staining. Immunohistochemical...

2013
Bo-xin Zhao Ya-bin Sun Sheng-qi Wang Lian Duan Qi-lu Huo Fei Ren Guo-feng Li

The expression and function of P-glycoprotein (P-gp) is associated with the phenotype of multi-drug resistance (MDR), leading chemotherapy failure of patients suffered with cancer. Grape seed procyanidin(GSP) is a natural polyphenol supplement with anti-inflammatory effect. Present study assessed a new use of GSP on the MDR reversal activity and its possible molecular mechanisms in MDR1-overpre...

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