Although neck and low-back pain are common sources of neuropathic pain with high societal costs, the pathophysiology ofneuropathic pain is not well-defined. Traditionally, most rodent pain studies rely on evoked reflex-based testing to measure pain.However, these testing methods do not reveal spontaneous pain, particularly early after injury. The rat grimace scale (RGS) forquantifying spontaneo...

The number of U.S. students who enter engineering programs in college is projected to drop, a trend that many believe will have a negative impact on the U.S. workforce (NAS et al., 2007; NAE and NRC, 2009). In addition, students who do pursue engineering degrees do not reflect the diversity of students in the United States, a pattern of enrollment that is likely to have a number of negative con...

Although bile acid transport by bile duct epithelial cells, or cholangiocytes, has been postulated, the details of this process remain unclear. Thus, we performed transport studies with [3H]taurocholate in confluent polarized monolayers of normal rat cholangiocytes (NRC). We observed unidirectional (i.e., apical to basolateral) Na+-dependent transcellular transport of [3H]taurocholate. Kinetic ...

Two experiments were conducted to assess effects of phase-feeding (PF) on broilers from 21 to 63 d. Experiment 1 evaluated the impact of PF on growth performance, whereas experiment 2 assessed the effects of PF on CP intake and nitrogen excretion. Diets were formulated using recommendations from NRC or linear regression equations. Two PF treatments were prepared: standard (PF) and low (PF10), i...

Human chromosome 3p cytogenetic abnormalities and loss of heterozygosity have been observed at high frequency in the nonpapillary form of sporadic renal cell carcinoma (RCC). The von Hippel-Lindau (VHL) gene has been identified as a tumor suppressor gene for RCC at 3p25, and functional studies as well as molecular genetic and cytogenetic analyses have suggested as many as two or three additiona...

At the Congress of the European Society of Cardiology (ESC) 2013, Amsterdam, many new trials were presented at the four Hot Line Sessions. Nine of these trials were simultaneously published in the New England Journal of Medicine (NEJM). In the Scientific Supplement of the Dutch daily newspaper, the NRC, it was put forward that seven out of the nine trials produced ‘negative’ results, leading to...

1.1 History of Accelerator Driven System Activities Since the early 1990’s, accelerator driven systems (ADS) – subcritical assemblies driven by high power proton accelerators through a spallation target which is neutronically coupled to the core – have been proposed for addressing certain missions in advanced nuclear fuel cycles. Institutes throughout the world have conducted numerous programs ...

esearch\nrc\frame_files\Generic Docs\Statistical Model\statistical coverNRC.fm DISCLAIMER This publication was prepared with the support of the U.S. Nuclear Regulatory Commission (NRC) Grant Program. This program supports basic, advanced, and developmental scientific research for a public purpose in areas related to nuclear safety. The grantee bears prime responsibility for the conduct of the r...

Using a functional genetic approach, we previously identified a novel genetic locus, NRC-1 (Nonpapillary Renal Cell Carcinoma 1), that mediated tumor suppression and rapid cell death of renal cell carcinoma (RCC) cells in vivo. For these experiments, a defined subchromosomal fragment of human chromosome 3p was transferred into a sporadic RCC cell line via microcell fusion, and microcell hybrid ...