Abstract Background Mild Behavioral Impairment is characterized by later life emergent and persistent neuropsychiatric symptoms (NPS). MBI domains include impaired drive/motivation, affective dysregulation, impulse dyscontrol, social inappropriateness, psychosis. We aimed to compare the relationship between NPS cognition in patients with subjective cognitive decline (SCD), mild impairment (MCI)...

The Nottingham prognostic index (NPI) is a widely used clinicopathological staging system for breast cancer prognostication. Using a step-wise classification approach where breast tumor expression profiles were first divided into general "molecular subtypes" [estrogen receptor (ER)+, ER-, ERBB2+], followed by an independent analysis of each subtype, we identified a 62-gene expression signature ...

1. Short introduction into neurophysiological assessment 2 1.1. Introducing EEG recording, EEG spectrum analysis and Event Related Potential analysis 2 1.2. Description of several EP and ERP protocols with relevance to psychiatry 8 2. Rationale of the use of EEG/EP/ERP protocols in psychiatry 14 2.1 Improved diagnostic precision 14 2.2. Better predicted treatment response 20 2.3. Shortened time...

The proteasome has been successfully targeted for the treatment of multiple myeloma and mantle cell lymphoma; however, in other hematologic malignancies, bortezomib has been less effective as a single agent. Here, we describe effects of NPI-0052, a novel proteasome inhibitor, in leukemia model systems. In cell lines, NPI-0052 inhibits all 3 proteolytic activities associated with the proteasome:...

The Nottingham prognostic index (NPI) is a widely used clinicopathological staging system for breast cancer prognostication. Using a step-wise classification approach where breast tumor expression profiles were first divided into general “molecular subtypes” [estrogen receptor (ER) , ER , ERBB2 ], followed by an independent analysis of each subtype, we identified a 62-gene expression signature ...

TRAIL promotes apoptotic tumor cell death; however, TRAIL-resistant tumors need to be sensitized to reverse resistance. Proteasome inhibitors potentiate TRAIL apoptosis in vitro and in vivo and correlate with up-regulation of death receptor 5 (DR5) via an unknown mechanism. We hypothesized that the proteasome inhibitor NPI-0052 inhibits the transcription repressor Yin Yang 1 (YY1) which regulat...

Pathologic complete response (pCR) prediction after neoadjuvant chemotherapy (NAC) is important for clinical decision-making in breast cancer. This study investigated the predictive value of Nottingham prognostic index (NPI), Immunohistochemical four (IHC4) score and a new predictive index combined with them in estrogen-positive (ER+) breast cancer following NAC. We retrospectively gathered cli...

Martin Salzmann-Erikson (2013): Caring in intensive psychiatry – rhythm and movements in a culture of stability. Örebro Studies in Care Sciences 47. The overall aim of this thesis is to describe and explore the concept of caring in intensive psychiatry. An initial inventory was made of nursing care activities in a PICU, based on an analysis of critical incidents. This inventory resulted in four...

OBJECTIVES To assess whether implementation of a stepwise multicomponent intervention (STA OP!) is effective in reducing challenging behavior and depression in nursing home residents with advanced dementia. DESIGN Cluster randomized controlled trial. SETTING Twenty-one clusters (single independent nursing home units) in 12 nursing homes within the Netherlands. PARTICIPANTS Residents with ...