Genetically determined obesities, involving leptin- and melanocortin-signaling pathways, have focused attention on the four medial hypothalamic nuclei as primary sources of feeding- and metabolically-based obesity. All four medial cell groups contain leptin receptors. To determine which of these cell groups normally mediates the effects of leptin on food intake and body weight gain, we injected...

Introduction Augmented renal clearance(ARC) of hydrophilic drugs is frequent in PICU patients and warrants adjustment standard dosing regimens to prevent therapeutic failure. Knowledge patient-, disease- therapy-related factors associated with ARC, would allow predict before the start treatment, which benefit from higher drug doses. We aimed identify predictors ARC critically ill children norma...

We show (under mild topological assumptions) that small oscillation of the unit normal vector implies Reifenberg flatness. We then apply this observation to the study of chord-arc domains and to a quantitative version of a two-phase free boundary problem for harmonic measure previously studied by Kenig-Toro [KT06].

We study the class of edge-transitive graphs of square-free order and valency at most k. It is shown that, except for a few special families of graphs, only finitely many members in this class are basic (namely, not a normal multicover of another member). Using this result, we determine the automorphism groups of locally primitive arc-transitive graphs with square-free order.

In this report I study the Kirchhoff equations, which are the basis for considering elastic filaments, in the context of a twisted planar ring. I apply an arc length preserving perturbation scheme that perturbs the basis used to describe the system directly, and analyse the generated normal mode solutions up to second-order. I also consider how these modes evolve in time.

in this paper we consider several generalizations of the skew t-normal distribution, and some of their properties. also, we represent several theorems for constructing each generalized skew t-normal distribution. next, we illustrate the application of the proposed distribution studying the ratio of two heavy metals, nickel and vanadium, associated with crude oil in shadgan wetland in the south-...

A study was conducted on the arc and melting efficiency of the plasma arc, gas tungsten arc, gas metal arc, and submerged arc welding processes. The results of this work are extended to develop a quantitative method for estimating weld metal dilution in a companion paper. Arc efficiency was determined as a function of current for each process using A36 steel base metal. Melting efficiency was e...

The plant growth retardant Phosfon inhibits cholesterol formation by cell·free preparations of normal liver and the Morris hepatomas 5123C, 7794A, and 9618A. In addition, both Phosfon and Amo 1618 arc active in inhibiting cholesterol synthesis from acetate and mevalonate in slices of host liver and the hepatomas. Fatty acid synthesis from acetate was also reduced in the presence of the retardants.

Recent phenomenological-theoretical studies' 4 have discussed var1ous poss1ble modes of coexistence of superconducting and magnetic order in those ternary compounds which exhibit re-entry from the superconducting state to a normal-resistive (but ferromagnetic) state. Thc dlscUsslons arc 811 based on 8 gcncrallzcd GlnzburgLandau model, fll st dcscrlbcd by K1cy. ' Oul notat10A 1s that of Ref. 3.

This study combines detailed geologic mapping, tephrochronology, U-Pb zircon dating, and published drill core data to evaluate the time transgressive 3-dimensional (thus 4-dimensional) structure evolution of two volcanoes on Hachijo-jima juvenile Izu-Bonin intra oceanic arc. The regional Ata-Torihama tephra (Ata-Th; 0.24 Ma) Kikai-Tozurahara (K-Tz; 0.095 from Kyushu are intercalated within volu...