Abstract Introduction Hyperchloraemic acidosis is known to be associated with impaired renal function in post-operative patients. We have experimentally investigated whether elevation chloride and hydrogen ions the potential negatively impact porcine vasculature. Methods Porcine (RA) mesenteric (MA) arteries were placed Krebs-Henseleit solution (K-H), gassed 95%O2/5%CO2, prepared for isometric ...

The rate of fatty acid synthesis in interscapular brown adipose tissue of female cold-adapted rats, as measured by the incorporation of 3H from 3H2O into tissue lipid, was decreased by about 70% after injection of noradrenaline. There was a similar decrease in the activity of acetyl-CoA carboxylase. In contrast, the proportion of pyruvate dehydrogenase in its active non-phosphorylated form was ...

Hepatorenal syndrome is a condition associated with very high mortality that may be reverted in some cases with vasoconstrictors. Terlipressin has generally been considered standard treatment, but noradrenaline has been postulated as alternative. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified six systematic reviews including four pertinent rand...

IAntinociceptive at the spinal level Adding NA is antinociceptive The story gets complicated because NA both inhibits and facilitates spinal nociceptive reflexes Spinal NA increases with acute and chronic nociceptive stimuli. NA tonically induces antinociception NA spinal denervation produces hyper and hypoalgesia NA spinal denervation retards the appearance of autotomy and neuropathic pain NA ...

Parkinson's disease (PD) is characterized by the degeneration of dopamine (DA) neurons in the substantia nigra pars compacta, and motor symptoms including bradykinesia, rigidity, and tremor at rest. These symptoms are exhibited when striatal dopamine concentration has decreased by around 70%. In addition to motor deficits, PD is also characterized by the non-motor symptoms. However, depletion o...

Noradrenaline injected into the perifornical region of the anterior part of the lateral hypothalamus in rats can serve as a reinforcement in a T maze learning, whether it induces the activation of the alimentary drive or not. It follows that the main role of noradrenaline in this brain area consists not so much in induction of the alimentary drive as in activation of the very process which is e...

1. Vascular reactivity and noradrenaline overflow were studied in Tyrode solution-perfused kidneys from young (6 weeks) normotensive and spontaneously hypertensive (SH) rats. 2. The vasoconstrictor response to nerve stimulation was greater in the kidneys from young SH rats than in those from young control rats. 3. Nerve stimulation evoked a greater release of noradrenaline in the kidneys from y...

Amine neurotransmitters, such as dopamine, serotonin, and noradrenaline, play important roles in the modulation of behaviors and metabolism of animals. InC. elegans, it has been shown that serotonin and octopamine, an invertebrate equivalent of noradrenaline, also regulate lifespan through a mechanism related to food deprivation-mediated lifespan extension. We have shown recently that dopamine ...

1. Studies with a sensitive radioenzymatic assay for plasma noradrenaline suggest there is a selective overactivity of the sympathetic nerous system in essential hypertension. 2. Serotonin turnover in the mesenteric vessels is approximately twice that of noradrenaline and it is suggested that serotonin may interact with noradrenaline to maintain vascular resistance. 3. Methodology which allows ...

1. Noradrenaline (1mm) and 5-hydroxytryptamine (1mm) stimulated the production of unesterified palmitate, oleate, stearate and arachidonate in nerve endings (synaptosomes) isolated from combined guinea-pig cerebral cortex and cerebellum. 2. Iproniazid phosphate (0.36mm) increased the concentrations of the same acids in osmotically ruptured synaptosomes. Further addition of 1mm-noradrenaline or ...