Although sepsis is the major cause of mortality and morbidity in the critically ill, precise mechanism(s) causing multiorgan dysfunction remain unclear. Findings of impaired oxygen utilization in septic patients and animals implicate nitric oxide-mediated inhibition of the mitochondrial respiratory chain. We recently reported a relationship between skeletal muscle mitochondrial dysfunction, cli...

background: this study was designed to assess the microleakage of glass-ionomer (gi), mineral trioxide aggregate (mta), and calcium-enriched mixture (cem) cement as coronal orifi ce barrier during walking bleaching. materials and methods: in this experimental study, endodontic treatment was done for 70 extracted human incisors without canal calcifi cation, caries, restoration, resorption, or cr...

an 11-year-old female patient was referred with a chief complaint of pain in the right mandibular second premolar. clinical and radiographic examinations showed secondary caries under an old composite restoration, a negative response to a pulp test and an immature root with an open apex. after root canal cleaning and shaping, bleeding was invoked in the canal up to 2 mm short of the cemento-ena...

OBJECTIVES The aim of this study was to determine an appropriate application duration of sodium ascorbate (SA) antioxidant gel in reducing microleakage of bonded composite restoration in intracoronally-bleached teeth. MATERIALS AND METHODS Eighty endodontically-treated human incisors were randomly divided into eight groups: control, no bleaching; IB and DB, immediate and delayed bonding after...

Malignant peripheral nerve sheath tumor is a malignant neoplasm that is rarely found in the oral cavity. About 50% of this tumor occurs in patients with neurofibromatosis type I and comprises approximately 10% of all soft tissue sarcomas of head and neck region. Intraosseous malignant peripheral nerve sheath tumor of the maxilla is rare. This article is the first to address malignant peripheral...

The renewed interest in donation after cardio-circulatory death (DCD) started in the 1990s following the limited success of the transplant community to expand the donation after brain-death (DBD) organ supply and following the request of potential DCD families. Since then, DCD organ procurement and transplantation activities have rapidly expanded, particularly for nonvital organs, like kidneys....

Apoptosis, or programmed cell death, is a general mechanism for removal of unwanted cells from the immune system. It is characterized by chromatin condensation, a reduction in cell volume, and endonuclease cleavage of DNA into oligonucleosomal length fragments. Apoptosis is also accompanied by a loss of membrane phospholipid asymmetry, resulting in the exposure of phosphatidylserine at the surf...

Introduction: The establishment of new therapeutic approaches for tissue repair and regeneration can be accelerated if adequate technologies for monitoring the repair process are developed. In craniomaxillofacial surgery, 96,000 bone graft procedures are performed each year to treat bone loss due to trauma or disease. Alas, autologous bone grafts are not always available, and additional surgery...

Fundamental events driving the pathological processes of septic shock-induced multiorgan failure (MOF) at the cellular and subcellular levels remain debated. Emerging data implicate mitochondrial dysfunction as a critical factor in the pathogenesis of sepsis-associated MOF. If macrocirculatory and microcirculatory dysfunctions undoubtedly participate in organ dysfunction at the early stage of s...