Formaldehyde is considered carcinogenic to humans by the IARC, but there are no previous reports of formaldehyde-DNA adducts in humans. In this study, we used liquid chromatography-electrospray ionization-tandem mass spectrometry to quantify the formaldehyde-DNA adduct N(6)-hydroxymethyldeoxyadenosine (N(6)-HOMe-dAdo) in leukocyte DNA samples from 32 smokers of >or=10 cigarettes per day and 30 ...

Startle eyeblink modification was measured during a degraded stimulus continuous performance test following both smoking and overnight abstinence among student smokers to measure the effects of smoking on both early and late attentional processes. A group of nonsmokers was tested twice without nicotine manipulation. A startling noise was presented either 240 or 1200 ms following target and nont...

OBJECTIVE To analyze the relation between smoking and passive smoking with heart rate variability parameters in male adolescents. METHODS The sample consisted of 1,152 males, aged 14 and 19 years. Data related to smoking and passive smoking were collected using a questionnaire. RR intervals were obtained by a heart rate monitor, on supine position, for 10 minutes. After collecting the RR inte...

Many case-control studies have been undertaken to assess whether and to what extent residential radon exposure is a risk factor for lung cancer. Nearly all these studies have been conducted in populations including smokers and nonsmokers. In this paper, we show that, depending on the nature of the joint effect of radon and tobacco on lung cancer risk, it may be very difficult to detect a main e...

We compared the cost-effectiveness of a free nicotine replacement therapy (NRT) program with a statewide smoke-free workplace policy in Minnesota. We conducted 1-year simulations of costs and benefits. The number of individuals who quit smoking and the quality-adjusted life years (QALYs) were the measures of benefits. After 1 year, a NRT program generated 18,500 quitters at a cost of 7020 dolla...

INTRODUCTION An employer-based cost-benefit analysis for varenicline versus bupropion was conducted using clinical outcomes from a recently published trial. METHODS A decision tree model was developed based on the net benefit of treatment to produce a nonsmoker at 1 year. Sensitivity analyses were conducted based on quit rates with placebo and varenicline and the cost of varenicline. RESULT...

Case report A man aged 67 years was admitted to hospital in January 1971 giving a history of sudden paralysis, in his right leg, which had occurred 10 days previously; this had been followed by gradual paralysis in his left leg. He had been incontinent of urine for 3 days. Recently he had lost 2 stone in weight, and had developed pains in his right shoulder. He worked in the dockyards of Portsm...

UNEXPECTED CORONARY THROMBOSIS INDUCED BY ANTIPHOSPHOLIPID SYNDROME (HUGHES SYNDROME) CASE REPORT (Abstract): Antiphospholipid syndrome (APS), one of the most common states of acquired hypercoagulability, is diagnosed by the persistent presence of antiphospholipid antibodies and recurrent episodes of vascular thrombosis. We present the case of a 39-year-old man late-presenting for cardiac rehab...

Case. A 33-year-old male nonsmoker presented with sudden onset of dyspnoea and thoracic pain. Chest radiograph showed a left-sided pneumothorax. Few days later he developed a right-sided pneumothorax. He had a positive family history of pneumothorax. High-resolution computed tomography of the chest showed multiple pulmonary cysts predominantly located in the lower lung regions. We suspected Bir...

A 42-year-old male nonsmoker presented with recurrent hemoptysis for 12 years requiring two hospitalizations and 11 units of blood transfusion, with occasional low-grade intermittent fever, and cough with scanty expectoration. Examination of lower respiratory system revealed biphasic and coarse crepitations over the left infrascapular area. Investigations revealed the following: Hb=75 gm/L; pla...