نتایج جستجو برای: nonoxidative

تعداد نتایج: 416  

Journal: :Cell host & microbe 2012
Chao-Tsung Yang C J Cambier J Muse Davis Christopher J Hall Philip S Crosier Lalita Ramakrishnan

Neutrophils are typically the first responders in host defense against invading pathogens, which they destroy by both oxidative and nonoxidative mechanisms. However, despite a longstanding recognition of neutrophil presence at disease sites in tuberculosis, their role in defense against mycobacteria is unclear. Here we exploit the genetic tractability and optical transparency of zebrafish to mo...

Journal: :Oncology reports 2006
Wilko I Staiger Johannes F Coy Rainer Grobholz Ralf-Dieter Hofheinz Nadine Lukan Stefan Post Matthias H Schwarzbach Frank Willeke

The nonoxidative pentose phosphate pathway allows glucose conversion to ribose for DNA or RNA synthesis and glucose degradation to lactate controlled by transketolase enzyme reactions. It has been postulated, that this pathway is of the utmost importance in tumors for the proliferation process. We detected a strong upregulation of the mutated transketolase transcript (TKTL1) in a considerable n...

Journal: :Assay and drug development technologies 2009
Paul A Johnston Caleb A Foster Marni Brisson Tierno Tong Ying Shun Sunita N Shinde William D Paquette Kay M Brummond Peter Wipf John S Lazo

The University of Pittsburgh Molecular Library Screening Center (Pittsburgh, PA) conducted a screen with the National Institutes of Health compound library for inhibitors of in vitro cell division cycle 25 protein (Cdc25) B activity during the pilot phase of the Molecular Library Screening Center Network. Seventy-nine (0.12%) of the 65,239 compounds screened at 10 muM met the active criterion o...

Journal: :Catalysts 2022

Nonoxidative dehydrogenation of isobutane is one the sustainable strategies for producing high value added isobutene. As alternatives commercial Pt- and Cr-based catalysts, supported V-based catalysts are worthy study. In this work, a series VOx/mMgAlO-R (m = 10, 15, 20, 25 30) were designed prepared by loading VOx on mMgAlO composite oxide supports derived from mesoporous Al2O3-supported layer...

2013
R. O. Ball

The objective of this study was to determine the Ile requirement in early (d 39 to 61) and late (d 89 to 109) pregnancy using the indicator AA oxidation method. The same 7 Large White × Landrace sows in their fourth parity were used in early and late pregnancy. Each sow received 6 diets based on corn, corn starch, and sugar in both early and late pregnancy at constant feed allowances (2.5 kg/d)...

Journal: :Infection and immunity 2005
Chen Du Richard Calderone John Richert Dongmei Li

The isolation and partial functional characterization of the two-component response regulator SSK1 gene of Candida albicans was previously reported. Compared to wild-type (CAF2-1) and gene-reconstituted (SSK23) strains, the ssk1 null strain (SSK21) was avirulent in a murine model of hematogenously disseminated candidiasis and less able to adhere to human esophageal cells. More recent data indic...

Journal: :Diabetes 2005
Pernille Poulsen Jørgen F P Wojtaszewski Inge Petersen Kaare Christensen Erik A Richter Henning Beck-Nielsen Allan Vaag

Storage of glucose as glycogen accounts for the largest proportion of muscle glucose metabolism during insulin infusion in normal and insulin-resistant subjects. Studies in first-degree relatives have indicated a genetic origin of the defective insulin activation of muscle glycogen synthase (GS) in type 2 diabetes. The aim of this study was to evaluate the relative impact of genetic versus nong...

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