1 “Politehnica” University of Bucharest, Applied Electronics and Information Engineering Department, E-mail: [email protected], rodica. [email protected]. 2 “Carol Davila” University of Medicine and Pharmacy, Obstretics and Gynecology Department, Bucharest, Romania, E-mail: ilinca. [email protected]. A NEW METHOD FOR FETAL ELECTROCARDIOGRAM DENOISING USING BLIND SOURCE SEPARATION AND EMPIRIC...

Fetal well-being was estimated by the enlargement of maternal abdomen, palpation of fetus on the abdomen, maternal perception of fetal kicking, and listening to fetal heart sound with obstetric stethoscope, in old age. Antique diagnosis of fetal life was fetal QRS found on limb lead electrocardiogram (ECG) studied by Cremer, which was progressed to fetal ECG amplifier composed of vacuum tube re...

The identification of cell-free fetal DNA (cffDNA) in maternal circulation has made non-invasive prenatal testing (NIPT) possible. Maternal plasma cell free DNA is a mixture of maternal and fetal DNA, of which, fetal DNA represents a minor population in maternal plasma. Therefore, methods with high sensitivity and precision are required to detect and differentiate fetal DNA from the large backg...

Chromosomal aneuploidy is the major reason why couples opt for prenatal diagnosis. Current methods for definitive diagnosis rely on invasive procedures, such as chorionic villus sampling and amniocentesis, and are associated with a risk of fetal miscarriage. Fetal DNA has been found in maternal plasma but exists as a minor fraction among a high background of maternal DNA. Hence, quantitative pe...

We evaluated the efficacy of noninvasive fetal Rhesus D (RHD) genotyping from maternal plasma in a highly admixed population. Fifty-five blood samples from RhD-negative pregnant women from Brazil were processed for extraction of cell-free plasma DNA. Real-time PCR was performed to amplify segments of exons 5 and 7 from the RHD gene, as well as for detection of the SRY gene to confirm the presen...

OBJECTIVES To determine the underlying biological basis for noninvasive prenatal testing (NIPT) results of multiple aneuploidies or autosomal monosomies. METHODS Retrospective analysis of 113,415 tests to determine the study cohort, consisting of 138 (0.12%) cases reported as a single autosomal monosomy (n = 65), single trisomy with a sex chromosome aneuploidy (n = 36), or with multiple aneup...

Objective. The aim of the study was to develop a complex electrophysiological measurement system (hardware and software) which uses the methods of electrophysiology and provides significant information about the intrauterine status of the fetus, intending to obtain true-to-form, morphologically evaluated fetal ECG from transabdominal maternal lead. Results. The present method contains many nove...

OBJECTIVE Compare the accuracy and reliability of fetal heart rate identification from maternal abdominal fetal electrocardiogram signals (ECG) and Doppler ultrasound with a fetal scalp electrode. DESIGN Prospective open method equivalence study. SETTING Three urban teaching hospitals in the Northeast United States. SAMPLE 75 women with normal pregnancies in labor at >37 weeks of gestatio...