Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent due to the worldwide obesity epidemic and currently affects one-third of adults or about one billion people worldwide. NAFLD is predicted to affect over 50% of the world's population by the end of the next decade. It is the most common form of liver disease and is associated with increased risk for progression to a mor...

Adiponectin, which plays a pivotal role in metabolic liver diseases, is reduced in concentration in patients with NASH (non-alcoholic steatohepatitis). The aim of the present study was to determine adiponectin concentrations in patients with different forms and stages of chronic liver diseases. Serum adiponectin concentrations were measured in 232 fasting patients with chronic liver disease: 64...

PURPOSE The aim of the study was to evaluate the association between coffee consumption and mortality from liver cirrhosis. METHODS We conducted a mortality follow-up of 51,306 adults who underwent screening for cardiovascular disease from 1977 to 1983. During the subsequent 17 years, the total number of deaths from all causes in the studied cohort was 4207. Fifty-three had the diagnosis of c...

This study investigated the 1-year mortality of patients who underwent brain surgery following traumatic brain injury (TBI) who also had alcoholic and/or nonalcoholic liver cirrhosis (LC) using a nationwide database in Taiwan. A longitudinal cohort study matched by propensity score with age, gender, length of ICU stay, HTN, DM, MI, stroke, HF, renal diseases, and year of TBI diagnosis in TBI pa...

Introduction Cirrhosis is the 12th leading cause of death in the United States, accounting for almost 30 thousand deaths per year (Starr 2011). !e leading causes of cirrhosis include chronic alcohol abuse and viral hepatitis; however cirrhosis is the common end pathway of several types of liver injury, including non-alcoholic fatty liver disease (NAFLD), autoimmune hepatic or biliary disease, a...

Non-alcoholic fatty liver disease (NAFLD) is a heterogeneous disease that may range from simple steatosis (non-alcoholic fatty liver, NAFL) to non-alcoholic steatohepatitis (NASH) which can progress to advanced fibrosis and cirrhosis and is currently one of the most common chronic liver diseases in Korea and worldwide. Furthermore, in parallel with the increasing prevalence of obesity, type 2 d...

Background: Cirrhosis is a common hepatological disorder seen in clinical practice. Liver plays an essential role in lipid metabolism, several stages of lipid synthesis and transportation. It is reasonable to expect an abnormal lipid profile in those with severe liver dysfunction Aim: To assess the lipid profile abnormalities in patients with cirrhosis of liver correlate with the severity of ci...

Abstract Background Alcohol-related liver disease (ALD) is a major cause of chronic diseases. Inflammatory response basic pathological feature ALD. Mucosal-associated invariant T(MAIT) cells are novel population innate immune cells, which may be depleted in various inflammatory However, the changes MAIT cell ALD remains unclear. Results In this study, levels were significantly decreased patient...

Increased serum bile salt levels have been associated to a single-nucleotide polymorphism in the bile salt export pump (BSEP; ABCB11) in several acquired cholestatic liver diseases but there is little evidence in alcoholic liver disease (ALD). Furthermore, a crosstalk between vitamin D and bile acid synthesis has recently been discovered. Whether this crosstalk has an influence on the course of...