Lack of the physiological nocturnal fall in blood pressure (BP) has been found in diabetics and it seems to be related to the presence of diabetic complications. The present study examined the changes in the nocturnal BP pattern of 8 normotensive insulin-dependent diabetic adolescents without nephropathy following improvement in glycemic control induced by an 8-day program of adequate diet and ...

Abstract Introduction Available, immediate-release oxybate products for narcolepsy require patients to awaken a second dose 2.5-4 h after the first cover full night of sleep. The investigational, extended-release once-nightly sodium (ON-SXB; FT218) eliminates this middle-of-the-night dosing. This interim analysis from ongoing RESTORE study (NCT04451668) assessed patient preferences ON-SXB versu...

A 62-year-old man with a past medical history presents to the cardiology clinic for evaluation after a routine echocardiogram obtained for evaluation of palpitations. His clinical history is remarkable for infrequent self-terminating episodes of regular rapid heartbeat over the last 2 months. The events are not associated with chest discomfort, dyspnea, lightheadedness, dizziness, or flushing. ...

222 Acute dyspnea may occur in the context of medical emergencies such as airway obstruction, pneumothorax, pulmonary embolism, and myocardial infarction. Chronic exertional dyspnea progressing to dyspnea at rest, as in this patient, suggests worsening pulmonary disease or heart failure. Orthopnea (dyspnea when supine) and trepopnea (dyspnea in the decubitus position) are suggestive of heart fa...

Sleep disorders and disruptive nocturnal behaviours are commonly reported in people with senile dementia and present both a significant clinical problem and a cause of increased stress for caregivers. Neuronal degeneration of cholinergic Nucleus basalis Meynert (NBM) neurons promote rest-activity disturbance and Sundowning in Alzheimer's disease. NBM neurons modulate the activity of the mainly ...

A free running circadian rest-activity cycle is rare in sighted individuals living in a normal environment. Even more rare is a periodicity shorter than 24 hours, as observed in actigraphic recordings in a female patient during convalescence after a whiplash injury in a car accident. The documented free running period was 22.5 hours for 19 days. During the subsequent weeks re-entrainment occurr...

Case presentation: A 73-yearold female smoker with a history of hypertension presents to the emergency room with dyspnea on exertion for 2 weeks, now progressing to shortness of breath at rest for 1 day. She has no angina, but has 2-pillow orthopnea and possible paroxysmal nocturnal dyspnea. On examination, blood pressure is 180/ 96 mm Hg, heart rate is 95 beats per minute and regular, and she ...

Power spectral density is an accepted measure of heart rate variability. Two estimators of multifractal properties: Wavelet Transform Modulus Maxima and Multifractal Detrended Fluctuation Analysis are used to investigate multifractal properties for the three strongly physiologically grounded components of power spectra: low frequency (LF), very low frequency (VLF) and ultra low frequency (ULV)....

A 27-year-old bricklayer was admitted to the South Tyrone Hospital, Dungannon, in August 1984. He gave a two-week history of shortness of breath and cough productive of green sputum. He had no chest pain, paroxysmal nocturnal dyspnoea, orthopnoea or peripheral oedema. He was a non-smoker and drank 12 pints of beer per week. He was pyrexial (temperature 99.80F) and dyspnoeic at rest. He had a co...

The ultradian alternation of rest/activity periods displayed by 10 C3H mice in diurnal condition, and by 10 others in nocturnal conditions, were compared with simulated sequences that respectively optimized three functional criteria, i.e. energy input, energy output, and net energy gain, accumulated over 11 consecutive hours. The simulated sequences were generated by means of a dynamic programm...