Background: The non-medical switch (NMS) from originator drugs to biosimilars is a possible strategy adopted by rheumatologists in order control the expansion of pharmaceutic costs for treatment fo patients affected chronic arthritis. To date, few real life data on adalimumab (ADA) its are available. Objectives: We aimed evaluate efficacy and safety single-Centre cohort arthritis who switched A...

Dr. Raz' speculations about the relation between placebo responsivity and hypnotizability are critically examined. While there is no generally accepted theoretical definition of hypnosis, there is a general consensus that hypnotizability can be reliably measured. In contrast, there seems to be a general consensus about a theoretical definition of placebo (including placebo effect, placebo respo...

PLACEBO EFFECTS IN MEDICINE1 For many years, the placebo response has been trivialized and even referred to as an “inert substance.” In a groundbreaking article recently published in The New England Journal of Medicine, Kaptchuk and Miller elucidate mechanisms underlying the placebo response and highlight findings to date regarding placebo effects. They note that placebo effects result from com...