nitric oxide (no) derived from activated macrophages has been shown to be crucial for the host's leishmanicidal activities. excess no, however, can in¬duce apoptosis in some cell types, including macrophages. in the present inves¬tigation, we studied the role of no in inducing apoptosis of balb/c mice mac¬rophages infected with leishmania major in vitro. the peritoneal macrophages were harveste...

abstractin the present work we set out to investigate the neuroprotective effects of noscapine (0.5-2 µm) in presence of d-glucose on primary murine foetal cortical neurons after oxygen–glucose deprivation/24 hrs recovery. cell viability, nitric oxide production and intracellular calcium ([ca2+]i) levels were evaluated by mtt assay, the modified griess method and fura-2 respectively. 25 and 100...

antibiotics are widely used as bacteriostatic and bactericidal drugs in bacterial infections. besides the respective interactions between the antibiotics and bacteria and between the immune system and bacteria, antibiotics also interact directly with the immune system and have various immunomodulatory effects on phagocytosis, chemotaxis, cytokine production and endotoxine release. in this stu...

objective: a number of studies have demonstrated the potential antitumor effects of saffron and its constituents on different malignant cells in vitro. it has been reported that a novel glycoconjugate isolated from corms and callus of saffron possesses cytotoxic activity against different tumor cellswith nitric oxide (no) production. these data suggest that the cytotoxic effect of saffron extra...