نتایج جستجو برای: nk1r

تعداد نتایج: 208  

2015
Shanna L. Bowman Amanda L. Soohoo Daniel J. Shiwarski Stefan Schulz Amynah A. Pradhan Manojkumar A. Puthenveedu

How neurons coordinate and reprogram multiple neurotransmitter signals is an area of broad interest. Here, we show that substance P (SP), a neuropeptide associated with inflammatory pain, reprograms opioid receptor recycling and signaling. SP, through activation of the neurokinin 1 (NK1R) receptor, increases the post-endocytic recycling of the mu-opioid receptor (MOR) in trigeminal ganglion (TG...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Silvia Pagliardini Tadafumi Adachi Jun Ren Gregory D Funk John J Greer

Elucidation of the neuronal mechanisms underlying respiratory rhythmogenesis is a major focal point in respiratory physiology. An area of the ventrolateral medulla, the pre-Bötzinger complex (preBotC), is a critical site. Attention is now focused on understanding the cellular and network properties within the preBotC that underlie this critical function. The inability to clearly identify key "r...

Journal: :Experimental Eye Research 2021

The inflammatory process plays a crucial role in frailty syndrome, which can appear middle age and is associated with poor health outcome. Consequently, gerontologists recommend screening biomarkers middle-aged adults to detect and, therefore, prevent chronic diseases mortality. External factors could be risk factor for because they generate extend the process. For these reasons, we analysed ef...

2015
Long-Jun Wu Hui Xu Shanelle W Ko Megumu Yoshimura Min Zhuo

Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in Molecular Pain (2005, 1:20), describes its potential role in feed-forward inhibition in lamina V of the dorsal horn of the spinal cord. This inhibition seems to function thro...

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