background: nitric oxide (no) is synthesized from l-arginine by a family of enzymes known as nitric oxide synthases. low concentrations of no is essential in biology and physiology of spermatozoa, but high amounts of no is toxic and has negative effects on sperm functions. moreover, sperm membrane contains high concentrations of polyunsaturated fatty acids that are highly susceptible to oxidati...

allergic rhinitis and asthma share common  epidemiological features and inflammatory processes. the aim of the present study was to document the influence of natural allergen exposure in exhaled no  (eno)  and in spirometric parameters of patients with seasonal allergic rhinitis(sar) and to investigate the differences among subjects with positive versus negative bronchial provocation to metacho...

the aim of the study was to assess the safety of nasal allergen challenge, and the use of certain parameters applied in assessing the condition of the respiratory system. we enrolled 30 patients diagnosed with allergy to common environmental allergens and 30 healthy controls. the safety of nasal challenge tests with an allergen was assessed by measuring the concentration of exhaled nitric oxide...

objective(s):to know whether scurrula atropurpurea is able to modulate total plasma nitrate/nitrite levels, decrease endothelial damage, and increase endothelial progenitor cells (epcs) in hypertensive rats. materials and methods: the rats were divided in 5 groups: control (normotensive) group, desoxy cortico sterone (doca)-salt hypertensive group, and three doca-salt hypertensive groups. all 5...

BACKGROUND Therapeutic hypothermia (TH) improves neurological outcomes after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). Although nitric oxide prevents organ injury induced by ischemia and reperfusion, role of nitric oxide during TH after CPR remains unclear. In this article, the authors examined the impact of endogenous nitric oxide synthesis on the beneficial effects of hypot...

Research during recent years has established nitric oxide as a unique signaling molecule that plays important roles in the regulation of the cardiovascular, nervous, immune, and other systems. Nitric oxide has also been implicated in the control of the secretion of hormones by the pancreas, hypothalamus, and anterior pituitary gland, and evidence is accumulating that it contributes to the regul...

Introduction: Salivary biomarkers may elucidate orodental inflammatory processes. Nitric oxide (NO) may help us to diagnose such changes . Methods: In this case-control study, all referral patients diagnosed with 130% sites were enrolled as generalized mild to moderate periodontitis group (PG). All PG and healthy control group (CG)’ individuals underwent scaling and root planning (SRP)...

Considerable confusion exists about the clinical use of exhaled nitric oxide measurement in general, and its bronchial and alveolar contributions in particular, for instance in response to treatment. An additional effect needs to be factored in when considering the degree of alveolar nitric oxide abnormality and its response to therapeutic interventions that may or may not be targeted to the lu...

–Stimulation of basal forebrain neurons elicits regional cerebral blood flow increases which are reportedly mediated by acetylcholine and nitric oxide. However, the modality of interaction between these two mediators remains unclear. Particularly, little is known about the source, i.e. endothelial, glial and/or neuronal, of the potent gaseous vasodilator nitric oxide. In the present study, we e...

Cyclosporine toxicity mainly affects kidney and liver function. We have previously shown that cyclosporine nephrotoxicity alters kidney nitric oxide synthase mRNA pattern of expression. To determine if nitric oxide synthase expression changes are mediated directly by cyclosporine or by secondary hemodynamic alterations induced by cyclosporine, we evaluated if these effects are tissue specific a...