The advantages of photo polymerization methods compared to thermal techniques are: rapid cure reactions, low energy demands, solvent free requirements and room temperature use. In order to form a macromer, polycaprolactone (PCL) was cross-linked via ultraviolet power with 2-isocyanatoethyl methacrylate. Different methods of characterization were carried out: estimation of swelling capacity, adh...

Anterior cruciate ligament (ACL) is the most frequently torn ligament in the knee, and complete healing is unlikely due to lack of vascularization. Current approaches for the treatment of ACL injuries include surgical interventions and grafting, however recent reports show that surgeries have 94% recurrency, and that repaired tissues are biomechanically inferior to the native tissue. These nece...

This study presents an innovative method for creating a highly porous surface with nanoscale roughness on biologically relevant polymers, specifically polyurethane (PU) and polycaprolactone (PCL). Nanoembossed polyurethane (NPU) and nanoembossed polycaprolactone (NPCL) were produced by the casting of PU and PCL over a plasma-deposited, spiky nanofeatured crystalline titanium (Ti) surface. The v...

Polycaprolactone (PCL) nanofibers incorporating azo dye/γ-cyclodextrin inclusion complex (Azo/γ-CD-IC) were successfully produced. The characteristics of the Azo/γ-CD-IC and PCL/Azo/γ-CD-IC investigated by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) thermogravimetric analysis (TGA). Based on SEM prepared nanofiber has a smooth surface with size diameter below 500 nm....

PURPOSE The aim of this study was to evaluate the survival, proliferation, and bone formation of dog mesenchymal stem cells (dMSCs) in the graft material by using Polycaprolactone-tricalcium phosphate (PCL-TCP), auto-fibrin glue (AFG), recombinant human bone morphogenetic protein-2 (rhBMP-2), and dMSCs after a transplantation to the scapula of adult beagle dogs. MATERIALS AND METHODS The subj...

Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. Scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...

The use of biodegradable polymers in tissue engineering has been widely researched due to their ability degrade and release components a controlled manner, allowing for the potential regeneration tissues. Melt blending is common method controlling degradation rate these polymers, which involves combining materials molten state create homogenous mixture with tailored properties. In this study, p...

The fibronectin type 10-peptide amphiphile (FNIII10-PA) was previously genetically engineered and showed osteogenic differentiation activity on rat bone marrow stem cells (rBMSCs). In this study, we investigated whether FNIII10-PA demonstrated cellular activity on polycaprolactone (PCL) fibers. FNIII10-PA significantly increased protein production and cell adhesion activity on PCL fibers in a d...

BACKGROUND Cartilage tissue engineering using synthetic scaffolds allows maintaining mechanical integrity and withstanding stress loads in the body, as well as providing a temporary substrate to which transplanted cells can adhere. PURPOSE This study evaluates the use of polycaprolactone (PCL) scaffolds for the regeneration of articular cartilage in a rabbit model. STUDY DESIGN Controlled l...

Bone transplants are used to treat fractures and increase new tissue development in bone tissue engineering. Grafting of massive implantations showing slow curing rate and results in cell death for poor vascularization. The potentials of biocomposite scaffolds to mimic extracellular matrix (ECM) and including new biomaterials could produce a better substitute for new bone tissue formation. A pu...