Increased arachidonic acid release occurred during activation of catecholamine secretion from cultured bovine adrenal medullary chromaffin cells. The nicotinic agonist 1,1-dimethyl-4- phenylpiperazinium (DMPP) caused an increased release of preincubated [3H]arachidonic acid over a time course which corresponded to the stimulation of catecholamine secretion. Like catecholamine secretion, the DMP...

To determine the effect of fatty acid availability on leucine metabolism, 14-h fasted dogs were infused with either glycerol or triglyceride plus heparin, and 46-h fasted dogs were infused with either nicotinic acid or nicotinic acid plus triglyceride and heparin. Leucine metabolism was assessed using a simultaneous infusion of L-[4,5-3H]leucine and alpha-[1-14C]ketoisocaproate. Leucine, alpha-...

We here have addressed the topic of the cross-talk between receptors. We provide evidence supporting the colocalization and the functional interaction between nicotinic acetylcholine receptors and some glutamatergic receptors. The recruitment of nicotinic acetylcholine receptors dynamically and negatively modulates the function of both Nmethyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-meth...

Women using oral contraceptives of the combined oestrogen-progestogen type excrete elevated levels of a number of metabolites of the tryptophan-nicotinic acid ribonucleotide metabolic pathway in urine collected after an oral dose of the amino acid. Increased excretions of Nl-methylnicotinamide reflect an enhanced capacity for the conversion of Ltryptophan to nicotinic acid derivatives, although...

The preparation of concentrates of the antipellagra vitamin which were active in the prevention of pellagra-like symptoms in chicks and the cure of black tongue in dogs was described previously (1). In this paper we wish to report additional work on the purification of the vitamin which led to the demonstration of the activity of nicotinic acid and nicotinic acid amide in the cure of canine bla...

Coffee is known as one of the most popular beverages around world. belongs to botanical family Rubiaceae and genus coffea. The two economically important species are C. arabica (arabica coffee) canephora (robusta coffee).The health benefits coffee due presence many biologically active components such caffeine, chlorogenic acid, nicotinic quinolinic trigonelline, tannic pyrogolic acid. postharve...

Measurement of cerebral blood flow by the nitrous oxide method before and during intravenous administration of nicotinic acid indicates that cerebral vessels do not respond to this drug. Evidence that contamination of cerebral by extracerebral blood occurs in about 20 per cent of subjects is adduced from the effects of nicotinic acid on the measured cerebral blood flows; studies making use of t...

The title compound, [Cd(C(6)H(4)NO(3))(2)(H(2)O)(4)], was obtained by the reaction of cadmium chloride with 5-hydroxy-nicotinic acid. The Cd(II) atom is located on an inversion centre and is coordinated by two N atoms from two 5-hydroxy-nicotinic acid ligands and four water mol-ecules in a distorted octa-hedral geometry. The structure is stabilized by inter-molecular O-H⋯O hydrogen bonds, formi...