Transport of newly synthesized lysosomal membrane proteins from the TGN (trans-Golgi network) to the lysosomes is due to the presence of specific signals in their cytoplasmic domains that are recognized by cytosolic adaptors. p40, a hypothetical transporter of 372 amino acids localized in the lysosomal membrane, contains four putative lysosomal sorting motifs in its sequence: three of the YXXph...

The Polar Regions have long been recognized as important sinks for the aerosol, including mercury derived from natural and anthropogenic sources at lower latitudes. The volatile metals like Hg and Pb introduce to atmosphere mostly through burning of fossil fuel. Generally, the distribution of mercury in environmental media is related to pH, oxygen content, organic matter, reducing agents and mi...

A novel, simple, sensitive and effective method has been developed for preconcentration of Ni (II) on functionalized Graphene oxide with covalently linked porphyrin (GO–H2NP) solid-phase extraction adsorbent. The stability of a chemical (GO–H2NP), especially in concentrated hydrochloric acid, was then used as a recycling and pre-concentration reagent. The method is based on selective chelation ...

In this study, a method was developed for determination of steroid hormones (17beta-estradiol, estrone, 17alpha-ethynylestradiol) in tap and sewage water samples from Sweden. Sample preparation and analysis were performed by a hollow-fibre microporous membrane liquid-liquid extraction (HF-MMLLE) set-up combined with gas chromatography-mass spectrometry (GC-MS). In this approach, only the organi...

A novel method for preconcentration of methylmercury and inorganic mercury from water samples was developed involving the determination of ngl(-1) levels of analytes retained on the silica C(18) solid sorbent, previous complexation with ammonium pyrrolidine dithiocarbamate (APDC), by slurry sampling cold vapor atomic absorption spectrometry (SS-CVAAS) in a flow injection (FI) system. Several va...

The brightness distribution of IRC +10216 at a wavelength of 11 microns has been measured in detail using a spatial interferometer. This brightness distribution appears to have azimuthal symmetry; an upper limit of 1.1 may be set to the ellipticity at 11 microns if the object has a major axis oriented either along or perpendicular to the major axis of the optical image. The radial distribution ...

ERBB2/HER-2 (HER-2/neu, NEU, NGL, HER-2, TKR1, CD340) is a 185 kDa transmembrane growth factor receptor and one of the four members of type 1 growth factor receptor family, designated HER1 to HER4 (c-erbB-1 to c-erbB-4). It has been shown to play a role in the signal transduction of cell growth but has no known natural ligand and instead seems to be activated via dimerisation with other recepto...

A total of 21 perfluorinated compounds (PFCs) were quantified in water and biota samples collected from Shenyang in North-east China and the Yangtze River Delta area in East China. The human health risk owing to intake of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) via fish and domestic poultry dietarywas evaluated. The total PFC concentration ( P PFC) in water samples fr...

A rapid gas chromatography-tandem mass spectrometry (GC-MS/MS) analytical method was developed for the simultaneous analysis of 7 estrogenic hormones (17α-estradiol, 17β-estradiol, estrone, mestranol, 17α-ethynylestradiol, levonorgestrel, estriol) and 5 androgenic hormones (testosterone, androsterone, etiocholanolone, dihydrotestosterone, androstenedione) in aqueous matrices. This method is uni...