purpose: to evaluate patients with advanced retinopathy of prematurity (rop) among neonates referred to poostchi rop clinic in shiraz from march 2006 to february 2008. methods: among referred infants to poostchi clinic for screening and management of rop, medical records of patients with advanced rop (stage 5) at initial examination or during disease progression were evaluated. information rega...

background: asphyxia is a common cause of perinatal mortality in 5-10% of all births worldwide. the present parameters for determining perinatal asphyxia, e.g. preeclampsia, cannot be considered as markers per se, and require auxiliary markers, e.g. increased number of nucleated red blood (nrbc) cells, for early diagnosis of perinatal asphyxia. objective: in this study, we evaluated the mean nr...

conclusions we concluded that the occurrence of urination, as a response to cooling stimulation of the lower trunk, is correlated with infants’ age and amount of environmental temperature degree. results micturition occurred in response to decreased skin temperature of the lower trunk, during the first minute interval of napkin removal, in 287 of the infants (35.9%). totally, 428 infants (53.5%...

Newborn screening has existed for approximately four decades. During that period of time, newborn screening has evolved conceptually from a laboratory test for a single disorder, phenylketonuria (PKU), to a multi-part public health system involving education, screening, diagnostic follow-up, treatment/management, and system evaluation. At a time when newborn screening is recognized as a model f...

Newborn screening is one of the most important public health initiatives to date, focusing on the identification of presymptomatic newborn infants with treatable conditions to reduce morbidity and mortality. The number of screening conditions continues to expand due to advances in screening technologies and the development of novel therapies. Consequently, some of the lysosomal storage disorder...

Galactosemia is an inborn error of galactose metabolism, caused by an abnormality in the conversion of galactose and uridine diphosphoglucose to glucose-1-phosphate and uridine diphosphogalactose through the action of 3 sequential enzymes: galactokinase (GALK), galactose- 1-phosphate uridyltransferase (GALT), and uridine phosphogalactose 4-epimerase (GALE). The advent of newborn screening broug...

In the course of the study on the hemoglobin contained in newborn bovine blood, two major and five minor components which are specific to newborn bovine hemoglobin were detected by the methods of agar-gel electrophoresis, cellulose-acetate membrane electrophoresis and column chromatography. These components were examined on their alkaline resistance , and the results showed that all the compone...

Previous techniques for seizure detection in newborn are inefficient. The main reason for their relative poor performance resides in their assumption of stationarity of the EEG. To remedy this problem, we use time-frequency distributions (TFD) to analyse and characterise the newborn EEG seizure patterns as a first step toward a time-frequency (TF) based seizure detection and classification sche...

The role of endotoxin in newborn septic shock is reviewed. Metabolic and cardiovascular changes, as known to us, are described with special emphasis that the newborn is not a "small adult." Developmental or maturational changes are hypothesized to be the major cause of these differences between age groups. Finally, it is our belief that newborn septic shock is an important topic for further inv...