Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correl...

Metastatic cell heterogeneity presents a significant obstacle to the development of targeted molecular and immunotherapeutics. Profiling of melanocyte differentiation antigens has revealed a nonstochastic, site-specific pattern of expression in metastases that was highest in brain, intermediate in soft tissues/lymph nodes, and lowest in visceral sites. Site-specific antigen heterogeneity, thus,...

This paper presents a new model of two-echelon periodic supply vessel planning problem with time windows mix of facility location (PSVPTWMFL-2E) in an offshore oil and gas industry. The new mixed-integer nonlinear programming (MINLP) modelconsists ofa fleet composition problem and a location-routing problem (LRP). The aim of the model is to determine the size and type of large vessels in the fi...

Finding minimum number of connecting lines is as important as locating power quality monitors (PQMs) for full observability of power system. Therefore, a PQM placement method should determine both optimum buses and lines, since utilities can make better decisions for monitoring of power system with this information. This paper attempted to propose a new method to locate the PQMs at various unob...

Pain is a useful sensation. Nociceptive pain provides warning of impending or actual tissue damage and prompts aversive or attentive actions that protect the body from harm. People who do not feel pain, due to mutation of certain ion channels (1), suffer a lifetime of otherwise avoidable injuries. The consequences of losing the ability to feel pain also are highlighted by the symptoms and clini...