cd19 is expressed on b- lineage cells and follicular dendritic cells and plays a key role in b cell malignancies and autoimmune diseases. thus, it has been considered as potential target for several monoclonal antibodies (mabs). for decades, chemotherapy has been known as one of the major antitumor therapies eradicating high proliferative tumor cells. but, anti- cd19 mabs developed for treating...

hydraulics of stepped spillway is a very complicated phenomenon, as it consists of a two phase flow passing through a set of designed steps. the steps increase the rate of energy dissipation taking place on the spillway face. turbulence, flow aeration and energy dissipation are the main tasks in the design of such structures. this study consists of the experimental investigation to determine th...

this paper introduces the general framework of a new system for material flow planning and operations and some of its important aspects. the justification for the new system stems from the short coming of mrp  i/mrp ii in term of its assumptions, particularly in relation to fixed lead times and effectively infinite production capacity. at the heart of the system is an automatic scheduler based ...

team-based learning is designed to provide students with both conceptual and procedural knowledge, aiming to enhance active learning and critical thinking. in the present study, team-based learning and lecture methods in teaching the “hospital organization and management” course among hospital management students were compared. this quasi-experimental study was conducted on 25 undergraduate stu...

in this paper we propose a simple non-parametric model for multiple crite-ria supplier selection problem. the proposed model does not generate a zeroweight for a certain criterion and ranks the suppliers without solving the modeln times (one linear programming (lp) for each supplier) and therefore allowsthe manager to get faster results. the methodology is illustrated using anexample.

The following study aims to present an innovative approach for Design. Participatory Design is the model of direct involvement of different social groups in the design from functional tools to environments, social institutions and businesses. Diverse collection of practices has been developed to support this direct involvement by Participatory Design. People are invited to participate during di...

This paper discusses an Interval Quadratic Programming (IQP) problem, where the constraints coefficients and the right-hand sides are represented by interval data. First, the focus is on a common method for solving Interval Linear Programming problem. Then the idea is extended to the IQP problem. Based on this method each IQP problem is reduced to two classical Quadratic Programming (QP) proble...

This paper proposes a simplified solution procedure to the model presented by Akinc and Roodman. The Benders’ decomposition procedure for analyzing this model has been developed, and its shortcomings have been highlighted. Here, the special nature of the problem is exploited which allowed us to develop a new algorithm through surrogating method. The two methods are compared by several numerical...

 nflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), has become one of the most common chronic conditions all over the world. The prevalence of IBD is growing rapidlyin developing countries along with nutrition transition. IBD affects children as well as adults, with 15-20% of patients being diagnosed during childhood. The onset of disea...