نتایج جستجو برای: neurotoxin

تعداد نتایج: 4465  

2001
MARITE BRADSHAW SEAN S. DINEEN WENYAN ZHANG ERIC A. JOHNSON

Botulinal neurotoxin continues to be a concern in food safety. The molecular biology of botulinal neurotoxin gene expression in Clostridium botuli-num is poorly understood. In this study, the transcriptional and translational kinetics of expression of type A botulinal neurotoxin by C. botulinum type A strains Hall A, 62A, and NCTC 2916 were determined during 96 hours of growth. Strains were gro...

Journal: :Aesthetic surgery journal 2009
Mitchell S Wortzman Andy Pickett

BACKGROUND Since the first comprehensive description of the physiologic effects of botulism toxicity in the 1820s, specific formulations of botulinum neurotoxin type A (BoNT-A) have been developed. Now, a new botulinum neurotoxin type A formulation (BoNTA-ABO; Dysport [abobotulinumtoxinA]; Medicis Aesthetics, Scottsdale, AZ) has been made available in the United States and these same physiologi...

2014
Samara Joy Nielsen Brian K Kit Yutaka Aoki Cynthia L Ogden

Background: Seafood is part of a healthy diet, but seafood can also contain methyl mercury—a neurotoxin. Objective: The objective was to describe seafood consumption in US adults and to explore the relation between seafood consumption

2014
YunZhou Yu Si Liu Yao Ma Zheng-Wei Gong Shuang Wang Zhi-Wei Sun

The clostridial neurotoxin (CNT) family includes botulinum neurotoxin (BoNT), serotypes A, B, E, and F of which can cause human botulism, and tetanus neurotoxin (TeNT), which is the causative agent of tetanus. This suggests that the greatest need is for a multivalent or multiagent vaccine that provides protection against all 5 agents. In this study, we investigated the feasibility of generating...

Journal: :Journal of rehabilitation medicine 2007
Paolo Manganotti Fabio Zaina Maurizio Falso Franco Milanese Antonio Fiaschi

OBJECTIVE To develop a clinical and instrumental protocol to assess the postural and dynamic effects following treatment with botulinum neurotoxin A in children with cerebral palsy affected by spastic equinus. DESIGN Open study, in which every patient served as his or her own control. PATIENTS Ten sequential children with cerebral palsy and spastic dynamic equinus foot. METHODS Botulinum ...

Journal: :Applied and environmental microbiology 2006
Shashi K Sharma Joseph L Ferreira Brian S Eblen Richard C Whiting

An amplified enzyme-linked immunosorbent assay (ELISA) for the detection of Clostridium botulinum complex neurotoxins was evaluated for its ability to detect these toxins in food. The assay was found to be suitable for detecting type A, B, E, and F botulinum neurotoxins in a variety of food matrices representing liquids, solid, and semisolid food. Specific foods included broccoli, orange juice,...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Anita Scheuber Rachel Rudge Lydia Danglot Graca Raposo Thomas Binz Jean-Christophe Poncer Thierry Galli

Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium. Exocytosis is compensated for by the reformation of vesicles at plasma membrane and endosomes. Although the adaptor complex AP-3 was proposed to be involved in the formation of SVs from endosomes, whether its f...

2015
Alison C. Savage Nicholas Buckley Jennifer Halliwell Christopher Gwenin Xiaohua He

Botulinum neurotoxin is one of the deadliest biological toxins known to mankind and is able to cause the debilitating disease botulism. The rapid detection of the different serotypes of botulinum neurotoxin is essential for both diagnosis of botulism and identifying the presence of toxin in potential cases of terrorism and food contamination. The modes of action of botulinum neurotoxins are wel...

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