In the present study, the authors reported on a case in neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE) with irreversible organic brain changes. The authors also longitudinally investigated serum brain-derived neurotrophic factor (BDNF) levels in the patient. We found that serum BDNF levels in the NPSLE patient with irreversible organic brain change were consistently low, ind...

NEUROPSYCHIATRIC SYMPTOMS and signs are a prominent part of systemic lupus erythematosus (SLE) and thrombotic thrombocytopenic purpura (TTP). These disorders are similar also in that they frequently share such clinical manifestations as hemolytic anemia, thrombocytopenia, renal disease, and fever. Adding to the complexity of diagnosis is the fact that patients may occasionally have clinical and...

NEUROPSYCHIATRIC SYMPTOMS and signs are a prominent part of systemic lupus erythematosus (SLE) and thrombotic thrombocytopenic purpura (TTP). These disorders are similar also in that they frequently share such clinical manifestations as hemolytic anemia, thrombocytopenia, renal disease, and fever. Adding to the complexity of diagnosis is the fact that patients may occasionally have clinical and...

Myelopathy, a severe condition characterised by paraparesis, sensory deficits and sphincter dysfunction, is one of the neuropsychiatric manifestations that have been described in patients with systemic lupus erythematosus (SLE). SLE-associated myelopathy may confront clinicians with a challenging decision-making process due to the broad differential diagnosis, the lack of disease-specific findi...

NEUROPSYCHIATRIC SYMPTOMS and signs are a prominent part of systemic lupus erythematosus (SLE) and thrombotic thrombocytopenic purpura (TTP). These disorders are similar also in that they frequently share such clinical manifestations as hemolytic anemia, thrombocytopenia, renal disease, and fever. Adding to the complexity of diagnosis is the fact that patients may occasionally have clinical and...

Objective The objective of this study was to investigate the association of clinical and renal disease activity with circulating sphingolipids in patients with systemic lupus erythematosus. Methods We used liquid chromatography tandem mass spectrometry to measure the levels of 27 sphingolipids in plasma from 107 female systemic lupus erythematosus patients and 23 controls selected using a desig...

Neuropsychiatric disorder is a severe complication in 14% to 75% of systemic lupus erythematosus (SLE) patients, which can result in significant morbidity. A 15-year-old female SLE patient with coexistence of dural sinus thrombosis and intracerebral hemorrhage resistant to two pulses of high dose of glucocorticoid was treated with anticoagulation of the low-molecular-weight [LMW] heparin subcut...

NEUROPSYCHIATRIC SYMPTOMS and signs are a prominent part of systemic lupus erythematosus (SLE) and thrombotic thrombocytopenic purpura (TTP). These disorders are similar also in that they frequently share such clinical manifestations as hemolytic anemia, thrombocytopenia, renal disease, and fever. Adding to the complexity of diagnosis is the fact that patients may occasionally have clinical and...

NEUROPSYCHIATRIC SYMPTOMS and signs are a prominent part of systemic lupus erythematosus (SLE) and thrombotic thrombocytopenic purpura (TTP). These disorders are similar also in that they frequently share such clinical manifestations as hemolytic anemia, thrombocytopenia, renal disease, and fever. Adding to the complexity of diagnosis is the fact that patients may occasionally have clinical and...

NEUROPSYCHIATRIC SYMPTOMS and signs are a prominent part of systemic lupus erythematosus (SLE) and thrombotic thrombocytopenic purpura (TTP). These disorders are similar also in that they frequently share such clinical manifestations as hemolytic anemia, thrombocytopenia, renal disease, and fever. Adding to the complexity of diagnosis is the fact that patients may occasionally have clinical and...