objective(s): targeting the neuropeptide systems has been shown to be useful for the development of more effective antipsychotic drugs. neurotensin, an endogenous neuropeptide, appears to be involved in the mechanism of action of antipsychotics. however, the available data provide conflicting results and the mechanism(s) by which antipsychotics affect brain neurotensin neurotransmission have no...

neuropeptides, possessing specific and functional receptors on various cells of the immune system, have the potential to regulate immune responses; and the macrophages as important components of defense against various agents, are at their influence. in this study the effect of neuropeptides substance p (sp) and calcitonin gene-related peptide (cgrp) on il-1 beta production by herpes sim¬plex t...

The development of a new integrated approach to the generation of a novel type of insect neuropeptide (Np) antagonists and putative insect control agents based on backbone cyclic compounds is described. The approach, termed the backbone cyclic neuropeptide-based antagonist (BBC-NBA), was applied to the insect pyrokinin (PK)/pheromone biosynthesis activating neuropeptide (PBAN) family as a model...

Neuropeptides represent the largest single class of signal compounds and are involved in regulation of development, growth, reproduction, metabolism and behavior of insects. Over the last few years there has been a tremendous increase in our knowledge of neuropeptide signaling due to genome sequencing, peptidomics, gene micro arrays, receptor characterization and targeted gene interference comb...

NEUROPEPTIDE Y (NPY) was identified as a neuropeptide that is colocalized and coreleased with the neurotransmitter norepinephrine from sympathetic nerve terminals. In this regard, a large body of research on NPY focused on its role in autonomic physiology and pharmacology as a potentiator of the postsynaptic actions of norepinephrine. However, with the increased understanding of the genes and t...

The paper outlines the role of oxytocin in regulating interpersonal communication patients with borderline personality disorder (BPD). According to neuropeptide model disorder, changes regulation secretion system are indicated as a potential mechanism deficits, which core that Numerous studies have confirmed reduced level this group people. In view finding, last dozen or so years, there been at...

s are listed in alphabetical order by the last name of the senior author. Identification and expression of Drosophila farnesoic acid o-methyltransferases (FaMeT): an enzyme potentially regulated by neuropeptides W.G. Bendena1, L. Dayton1 and S.S. Tobe2 1Department of Biology, Queen’s University, Kingston ON, Canada. [email protected] 2University of Toronto, Toronto Ontario, Canada. Ju...